ChEMBL ligand: CHEMBL473967
Acyl coenzyme A:cholesterol acyltransferase 1 in Human [ChEMBL: CHEMBL2782] [UniProtKB: P35610] There should be some charts here, you may need to enable JavaScript!
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907] diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Rat [ChEMBL: CHEMBL6129] [GtoPdb: 2821] [UniProtKB: Q9ERM3] There should be some charts here, you may need to enable JavaScript!
diacylglycerol O-acyltransferase 2/Diacylglycerol O-acyltransferase 2 in Human [ChEMBL: CHEMBL5853] [GtoPdb: 3211] [UniProtKB: Q96PD7] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acyl coenzyme A:cholesterol acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2782] [UniProtKB: P35610]
ChEMBL	Inhibition of human ACAT1 at 10 uM by liquid scintillography	B	4.92	pIC50	12000	nM	IC50	J Med Chem (2009) 52: 1558-1568 [PMID:19256504]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907]
ChEMBL	Inhibition of human DGAT1 expressed in baculovirus infected insect cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assay	B	6.95	pIC50	113	nM	IC50	J Med Chem (2011) 54: 2433-2446 [PMID:21413799]
ChEMBL	Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation counting	B	7.14	pIC50	72	nM	IC50	ACS Med Chem Lett (2011) 2: 407-412 [PMID:24900321]
ChEMBL	Inhibition of human DGAT1	B	7.14	pIC50	72	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6122-6125 [PMID:21908190]
ChEMBL	Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta counting	B	7.8	pIC50	16	nM	IC50	ACS Med Chem Lett (2011) 2: 407-412 [PMID:24900321]
GtoPdb	-	-	7.82	pIC50	15	nM	IC50	J Med Chem (2009) 52: 1558-68 [PMID:19256504]
ChEMBL	Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography	B	7.82	pIC50	15	nM	IC50	J Med Chem (2009) 52: 1558-1568 [PMID:19256504]
ChEMBL	Inhibition of human DGAT-1-mediated triglyceride synthesis in the HT-29 cells by whole cell assay	B	8.1	pIC50	8	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6122-6125 [PMID:21908190]
ChEMBL	Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA	B	8.22	pIC50	6	nM	IC50	J Med Chem (2014) 57: 3464-3483 [PMID:24670009]
ChEMBL	Inhibition of DGAT1 (unknown origin) by cell-based assay	B	8.4	pIC50	4	nM	IC50	J Med Chem (2014) 57: 3464-3483 [PMID:24670009]
ChEMBL	Inhibition of human DGAT1 expressed in CHO-K1 cells after 1 hr using palmitoyl-1-14C-coenzyme A by phospholipid flashplate assay	B	5.84	pEC50	1436	nM	EC50	J Med Chem (2011) 54: 2433-2446 [PMID:21413799]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6129] [GtoPdb: 2821] [UniProtKB: Q9ERM3]
ChEMBL	Inhibition of DGAT in rat liver microsomes	B	5.51	pIC50	3100	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7456-7460 [PMID:23141914]
ChEMBL	Inhibition of rat microsomal DGAT1 by liquid scintillography	B	7.72	pIC50	19	nM	IC50	J Med Chem (2009) 52: 1558-1568 [PMID:19256504]
diacylglycerol O-acyltransferase 2/Diacylglycerol O-acyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5853] [GtoPdb: 3211] [UniProtKB: Q96PD7]
ChEMBL	Inhibition of human DGAT-2	B	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2011) 2: 407-412 [PMID:24900321]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG by patch clamp assay	B	5	pIC50	>10000	nM	IC50	J Med Chem (2014) 57: 3464-3483 [PMID:24670009]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]