ChEMBL ligand: CHEMBL3092413
GPR39/G-protein coupled receptor 39 in Human [ChEMBL: CHEMBL3091266] [GtoPdb: 105] [UniProtKB: O43194] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A/Phosphodiesterase 3A in Human [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3B/Phosphodiesterase 3B in Human [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR39/G-protein coupled receptor 39 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3091266] [GtoPdb: 105] [UniProtKB: O43194]
ChEMBL	Agonist activity at recombinant human GPR39 expressed in CHO-K1 cells assessed as increase of Zn2+-induced cAMP production preincubated for 30 mins measured after 60 mins	F	4.92	pEC50	12000	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
ChEMBL	Agonist activity at human GPR39 receptor expressed in CHO cells assessed as increase in ca2+ flux	F	5.2	pEC50	6250	nM	EC50	Bioorg Med Chem Lett (2022) 61: 128607-128607 [PMID:35123006]
ChEMBL	Agonist activity at GPR39 in human HT-29 cells assessed as increase in intracellular Ca2+ mobilization after 72 hrs by FLIPR assay	F	6.05	pEC50	900	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
GtoPdb	-	-	7.2	pEC50	59	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-84 [PMID:24900608]
ChEMBL	Agonist activity at recombinant human GPR39 expressed in CHO-K1 cells assessed as increase of Zn2+-induced intracellular Ca+2 mobilization after 1 hr by Fluo-4 No staining-based FLIPR assay	B	7.25	pEC50	56	nM	EC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
phosphodiesterase 3A/Phosphodiesterase 3A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL241] [GtoPdb: 1298] [UniProtKB: Q14432]
ChEMBL	Inhibition of PDE3a (unknown origin)	B	4.82	pIC50	15000	nM	IC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]
phosphodiesterase 3B/Phosphodiesterase 3B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL290] [GtoPdb: 1299] [UniProtKB: Q13370]
ChEMBL	Inhibition of PDE3B (unknown origin)	B	4.62	pIC50	24000	nM	IC50	ACS Med Chem Lett (2013) 4: 1079-1084 [PMID:24900608]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]