ChEMBL ligand: CHEMBL504559 (SM-337)
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] There should be some charts here, you may need to enable JavaScript!
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09] There should be some charts here, you may need to enable JavaScript!
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490]
GtoPdb	Fluorescence polarization assay using hcIAP-1 BIR3 domain (residues 253-363)	-	8.82	pKi	1.5	nM	Ki	J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL	Displacement of fluorescently tagged SM5F from human cIAP-1 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay	B	8.82	pKi	1.5	nM	Ki	J Med Chem (2008) 51: 8158-8162 [PMID:19049347]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	8.89	pKi	1.3	nM	Ki	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	8.05	pIC50	9	nM	IC50	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	8.2	pKi	6.3	nM	Ki	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
GtoPdb	Fluorescence polarization assay using hcIAP2 BIR3 domain (residues 238-349)	-	8.38	pKi	4.2	nM	Ki	J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	7.58	pIC50	26.3	nM	IC50	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
baculoviral IAP repeat containing 8/Baculoviral IAP repeat-containing protein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5851] [GtoPdb: 2797] [UniProtKB: Q96P09]
ChEMBL	Displacement of fluorescently tagged SM5F from human cIAP-2 BIR3 expressed in Escherichia coli BL21 cells by fluorescence polarization assay	B	8.38	pKi	4.2	nM	Ki	J Med Chem (2008) 51: 8158-8162 [PMID:19049347]
X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	6.96	pKi	110.9	nM	Ki	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]
GtoPdb	Fluorescence polarization assay using hXIAP BIR3 domain (residues 241-356)	-	7.59	pKi	26	nM	Ki	J Med Chem (2008) 51: 8158-62 [PMID:19049347]
ChEMBL	Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay	B	6.43	pIC50	369.7	nM	IC50	J Med Chem (2010) 53: 6361-6367 [PMID:20684551]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]