AZD5582 [Ligand Id: 7710] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3108827 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] | ||||||||
| GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-919 [PMID:24320998] |
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged cIAP1 BIR3 domain (L250 to G350) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| ChEMBL | Binding affinity to cIAP1 in human MDA-MB-231 cells assessed as induction of protein degradation after 1 hr by ELISA | B | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] | ||||||||
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged cIAP2 BIR3 domain (I235 to A336) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| GtoPdb | - | - | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 9897-919 [PMID:24320998] |
| X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] | ||||||||
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged XIAP BIR2 domain (R214 to P260) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-919 [PMID:24320998] |
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged XIAP BIR3 domain (N252 to E350) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
