AZD5582 [Ligand Id: 7710] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3108827 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] | ||||||||
| GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-919 [PMID:24320998] |
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged cIAP1 BIR3 domain (L250 to G350) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| ChEMBL | Binding affinity to cIAP1 in human MDA-MB-231 cells assessed as induction of protein degradation after 1 hr by ELISA | B | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] | ||||||||
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged cIAP2 BIR3 domain (I235 to A336) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| GtoPdb | - | - | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 9897-919 [PMID:24320998] |
| X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] | ||||||||
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged XIAP BIR2 domain (R214 to P260) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
| GtoPdb | - | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-919 [PMID:24320998] |
| ChEMBL | Displacement of AbuRPFK-5FAM from GST-tagged XIAP BIR3 domain (N252 to E350) (unknown origin) after 20 mins by fluorescence polarization assay | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2013) 56: 9897-9919 [PMID:24320998] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
