ML277 [Ligand Id: 7666] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL2070953
There should be some charts here, you may need to enable JavaScript!
  • Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787]
There should be some charts here, you may need to enable JavaScript!
  • Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526]
There should be some charts here, you may need to enable JavaScript!
  • Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG expressed in CHO cells after 3 mins by patch clamp assay B 4.52 pIC50 >30000 nM IC50 Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039]
Kv7.1/Voltage-gated potassium channel subunit Kv7.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1866] [GtoPdb: 560] [UniProtKB: P51787]
ChEMBL Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay B 6.59 pEC50 260 nM EC50 Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039]
GtoPdb - - 6.6 pEC50 260 nM EC50 Bioorg Med Chem Lett (2012) 22: 5936-41 [PMID:22910039]
Kv7.2/Voltage-gated potassium channel subunit Kv7.2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2476] [GtoPdb: 561] [UniProtKB: O43526]
ChEMBL Activation of KCNQ2 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control B 4.52 pEC50 >30000 nM EC50 Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039]
Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
ChEMBL Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control B 4.52 pEC50 >30000 nM EC50 Bioorg Med Chem Lett (2012) 22: 5936-5941 [PMID:22910039]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]