ML213 [Ligand Id: 7665] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1703636
  • Kv7.4/Potassium voltage-gated channel subfamily KQT member 4 in Human [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
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  • Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human [ChEMBL: CHEMBL2221348] [GtoPdb: 562, 561] [UniProtKB: O43525, O43526]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv7.4/Potassium voltage-gated channel subfamily KQT member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
ChEMBL Activation of human Kv7.4 by patch clamp method B 5.8 pEC50 1600 nM EC50 Bioorg Med Chem Lett (2018) 28: 3793-3797 [PMID:30327146]
GtoPdb - - 6.3 pEC50 510 nM EC50 ACS Chem Neurosci (2011) 2: 572-577 [PMID:22125664]
Kv7.3/Kv7.5/Voltage-gated potassium channel KCNQ3/KCNQ5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3883311] [GtoPdb: 562, 564] [UniProtKB: O43525, Q9NR82]
ChEMBL Activation of human Kv7.3/7.5 by patch clamp method B 6.3 pEC50 500 nM EC50 Bioorg Med Chem Lett (2018) 28: 3793-3797 [PMID:30327146]
Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221348] [GtoPdb: 562, 561] [UniProtKB: O43525, O43526]
ChEMBL Activation of human Kv7.2/7.3 by patch clamp method B 7.4 pEC50 40 nM EC50 Bioorg Med Chem Lett (2018) 28: 3793-3797 [PMID:30327146]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]