ML213 [Ligand Id: 7665] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1703636
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  • Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human [ChEMBL: CHEMBL2221348] [GtoPdb: 562, 561] [UniProtKB: O43525, O43526]
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  • Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv7.3/Kv7.5/Voltage-gated potassium channel KCNQ3/KCNQ5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3883311] [GtoPdb: 562, 564] [UniProtKB: O43525, Q9NR82]
ChEMBL Activation of human Kv7.3/7.5 by patch clamp method B 6.3 pEC50 500 nM EC50 Bioorg Med Chem Lett (2018) 28: 3793-3797 [PMID:30327146]
Kv7.3/Kv7.2/Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2221348] [GtoPdb: 562, 561] [UniProtKB: O43525, O43526]
ChEMBL Activation of human Kv7.2/7.3 by patch clamp method B 7.4 pEC50 40 nM EC50 Bioorg Med Chem Lett (2018) 28: 3793-3797 [PMID:30327146]
Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
ChEMBL Activation of human Kv7.4 by patch clamp method B 5.8 pEC50 1600 nM EC50 Bioorg Med Chem Lett (2018) 28: 3793-3797 [PMID:30327146]
GtoPdb - - 6.3 pEC50 510 nM EC50 ACS Chem Neurosci (2011) 2: 572-577 [PMID:22125664]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]