KB-130015 [Ligand Id: 7659] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL157885 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor-α/Thyroid hormone receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1860] [GtoPdb: 588] [UniProtKB: P10827] | ||||||||
| ChEMBL | Concentration required to inhibit 50% of binding of [125I]-T3 to human Thyroid hormone receptor alpha-1 in CHO-K1 cells | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (2002) 45: 623-630 [PMID:11806713] |
| ChEMBL | Inhibitory activity against human Thyroid hormone receptor alpha | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (2005) 48: 3114-3117 [PMID:15857115] |
| ChEMBL | Inhibitory activity against human TRAFalpha | B | 5.66 | pIC50 | 2200 | nM | IC50 | J Med Chem (2005) 48: 3114-3117 [PMID:15857115] |
| Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1947] [GtoPdb: 589] [UniProtKB: P10828] | ||||||||
| ChEMBL | Inhibition of human thyroid hormone receptor beta 1 | B | 5.29 | pIC50 | 5128.61 | nM | IC50 | Bioorg Med Chem (2007) 15: 5251-5261 [PMID:17524652] |
| ChEMBL | Concentration required to inhibit 50% of binding of [125I]T3 to human Thyroid hormone receptor beta 1 in CHO-K1 cells | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Med Chem (2002) 45: 623-630 [PMID:11806713] |
| ChEMBL | Inhibitory activity against human Thyroid hormone receptor beta | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Med Chem (2005) 48: 3114-3117 [PMID:15857115] |
| ChEMBL | Inhibitory activity against human TRAFbeta | B | 5.39 | pIC50 | 4100 | nM | IC50 | J Med Chem (2005) 48: 3114-3117 [PMID:15857115] |
| Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| GtoPdb | - | - | 4.9 | pEC50 | - | - | - | Eur J Pharmacol (2010) 632: 52-9 [PMID:20097192] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
