ChEMBL ligand: CHEMBL428880 (Acide cromoglicique, Acido cromoglicico, Cromo-comod, Cromoglicate, Cromoglicic acid, Cromoglycate, Cromolyn, R03BC01)
GPR35/G-protein coupled receptor 35 in Human [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] GPR35/G-protein coupled receptor 35 in Mouse [ChEMBL: CHEMBL2390813] [GtoPdb: 102] [UniProtKB: Q9ES90] There should be some charts here, you may need to enable JavaScript!
TAS2R7 in Human [GtoPdb: 663] [UniProtKB: Q9NYW3] There should be some charts here, you may need to enable JavaScript!
TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97]
ChEMBL	Competitive binding affinity to Nluc-fused human GPR35 expressed in CHO-K1 cells assessed as inhibition constant using furimazine as substrate incubated for 30 mins followed by substrate addition by in presence of 10-(4-(2-(4-(4-((2,8-dicarboxy-6-hydroxy-10-methylpyrido[3,2-g]quinolin-4-yl)oxy)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)phenyl)-5,5-difluoro-2,7,9-trimethyl-5H-imidazo[1,2-c]pyrrolo[2,1-f][1,3,2]diazaborinin-6-ium-5-uide	B	5.53	pKi	2970	nM	Ki	ACS Med Chem Lett (2023) 14: 411-416 [PMID:37077394]
ChEMBL	Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis	B	5.63	pKi	2340	nM	Ki	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Agonist activity at human GPR35 by beta-arrestin recruitment assay	F	5.1	pEC50	8000	nM	EC50	Bioorg Med Chem (2023) 96: 117511-117511 [PMID:37976806]
ChEMBL	Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay	B	5.15	pEC50	7000	nM	EC50	J Med Chem (2017) 60: 362-372 [PMID:27976894]
ChEMBL	Agonist activity at GPR-35 (unknown origin) by beta-arrestin assay	B	5.15	pEC50	7000	nM	EC50	ACS Med Chem Lett (2023) 14: 411-416 [PMID:37077394]
ChEMBL	Agonist activity at human GPR35 by DMR assay	B	6.28	pEC50	520	nM	EC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Agonist activity at GPR-35 (unknown origin) expressed in HT-29 cells by DMR assay	B	6.28	pEC50	520	nM	EC50	ACS Med Chem Lett (2023) 14: 411-416 [PMID:37077394]
ChEMBL	Agonist activity at human GPR35 by Ca+2 release assay	B	6.68	pEC50	210	nM	EC50	J Med Chem (2013) 56: 7084-7099 [PMID:23888932]
ChEMBL	Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay	B	7.28	pEC50	52	nM	EC50	J Med Chem (2017) 60: 362-372 [PMID:27976894]
GPR35/G-protein coupled receptor 35 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2390813] [GtoPdb: 102] [UniProtKB: Q9ES90]
ChEMBL	Agonist activity at mouse GPR35 by beta-arrestin recruitment assay	F	4.24	pEC50	58000	nM	EC50	Bioorg Med Chem (2023) 96: 117511-117511 [PMID:37976806]
TAS2R7 in Human [GtoPdb: 663] [UniProtKB: Q9NYW3]
GtoPdb	-	-	2.35	pEC50	4500000	nM	EC50	Chem Senses (2010) 35: 157-70 [PMID:20022913]
TAS2R20 in Human [GtoPdb: 671] [UniProtKB: P59543]
GtoPdb	-	-	4.35	pEC50	45000	nM	EC50	Chem Senses (2010) 35: 157-70 [PMID:20022913]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]