ciclesonide [Ligand Id: 7469] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2040682 (Alvesco, Alvesco 160, Alvesco 80, Aservo equihaler, BI54903, Ciclesonida, Ciclesonide, Omnaris, RPR-251526, RPR251526, Zetonna) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| GtoPdb | - | - | 7.43 | pKi | 37 | nM | Ki | J Pharmacol Exp Ther (2005) 314: 568-74 [PMID:15878996] |
| ChEMBL | Inhibition of glucocorticoid receptor (unknown origin) | B | 8.7 | pIC50 | 2 | nM | IC50 | RSC Med Chem (2024) 15: 809-831 [PMID:38516594] |
| ChEMBL | Agonist activity at glucocorticoid receptor (unknown origin) expressed in K562 cells | B | 7.66 | pEC50 | 22 | nM | EC50 | RSC Med Chem (2024) 15: 809-831 [PMID:38516594] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
