birinapant [Ligand Id: 7432] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3039522 (Birinapant, TL-32711, TL32711) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| baculoviral IAP repeat containing 2/Baculoviral IAP repeat-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5462] [GtoPdb: 2791] [UniProtKB: Q13490] | ||||||||
| GtoPdb | - | - | 9 | pKd | <1 | nM | Kd | Breast Cancer Res Treat (2013) 137: 359-71 [PMID:23225169] |
| ChEMBL | Binding affinity to cIAP1-BIR3 domain (unknown origin) | B | 9 | pKd | 1 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| ChEMBL | Binding affinity to human N-terminal His-tagged cIAP1 BIR2-3 C202A/C213G mutant after 60 mins by HTRF assay | B | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (2015) 58: 1556-1562 [PMID:25584393] |
| baculoviral IAP repeat containing 3/Baculoviral IAP repeat-containing protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5335] [GtoPdb: 2792] [UniProtKB: Q13489] | ||||||||
| ChEMBL | Binding affinity to cIAP2-BIR3 domain (unknown origin) | B | 7.44 | pKd | 36 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| baculoviral IAP repeat containing 7/Baculoviral IAP repeat-containing protein 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075127] [GtoPdb: 2794] [UniProtKB: Q96CA5] | ||||||||
| ChEMBL | Binding affinity to ML-IAP-BIR domain (unknown origin) | B | 9 | pKd | 1 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| Genome polyprotein in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523954] [UniProtKB: A0A024AXB9] | ||||||||
| ChEMBL | Inhibition of Zika virus NS2B-NS3 protease by cell based assay | B | 6.52 | pEC50 | 300 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126965-126965 [PMID:31980339] |
| X-linked inhibitor of apoptosis/Inhibitor of apoptosis protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4198] [GtoPdb: 2790] [UniProtKB: P98170] | ||||||||
| ChEMBL | Binding affinity to XIAP-BIR3 domain (unknown origin) | B | 7.3 | pKd | 50 | nM | Kd | J Med Chem (2019) 62: 5750-5772 [PMID:30676015] |
| GtoPdb | - | - | 7.35 | pKd | 45 | nM | Kd | Breast Cancer Res Treat (2013) 137: 359-71 [PMID:23225169] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
