zenarestat [Ligand Id: 7418] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL10413 (CI-1014, FK-366, FR-74366, Zenarestat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
| ChEMBL | In vitro inhibition of recombinant human aldehyde reductase | B | 5 | pIC50 | 9900 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| GtoPdb | In vitro inhibition of recombinant human aldehyde reductase | - | 5 | pIC50 | 9900 | nM | IC50 | J Med Chem (2005) 48: 3141-52 [PMID:15857120] |
| ChEMBL | Inhibition of aldose reductase | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem (2007) 15: 7865-7877 [PMID:17870536] |
| ChEMBL | Inhibitory Activity against Human recombinant Aldose Reductase (wild type) | B | 7.37 | pIC50 | 42.4 | nM | IC50 | J Med Chem (2000) 43: 1062-1070 [PMID:10737739] |
| ChEMBL | In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2005) 48: 3141-3152 [PMID:15857120] |
| Aldose reductase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4559] [UniProtKB: P80276] | ||||||||
| ChEMBL | Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrate | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1677-1682 |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibitory activity against purified rat lens aldose reductase (RLAR) | B | 8.36 | pIC50 | 4.4 | nM | IC50 | J Med Chem (1994) 37: 787-792 [PMID:8145228] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
