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ChEMBL ligand: CHEMBL1187833 (GSK-573719, GSK573719, Umeclidinium, Umeclidinium cation, Umeclidinium ion) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
GtoPdb | - | - | 9.8 | pKi | 0.16 | nM | Ki |
J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 9.82 | pKi | 0.15 | nM | Ki |
J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
GtoPdb | - | - | 10.22 | pKi | 0.06 | nM | Ki |
J Med Chem (2009) 52: 2493-505 [PMID:19317446]; J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
GtoPdb | - | - | 10.3 | pKi | - | - | - | J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
M5 receptor in Human [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
GtoPdb | - | - | 9.9 | pKi | - | - | - | J Pharmacol Exp Ther (2013) 345: 260-70 [PMID:23435542] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]