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ChEMBL ligand: CHEMBL196945 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
ChEMBL | Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL) | F | 4.39 | pIC50 | 41000 | nM | IC50 | J Med Chem (2005) 48: 5705-5720 [PMID:16134939] |
ChEMBL | Concentration required to inhibit A beta 40 peptide 100 uM | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2005) 48: 5705-5720 [PMID:16134939] |
presenilin 1/presenilin 2/Gamma-secretase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094135] [GtoPdb: 2402, 2403] [UniProtKB: P49768, P49810, Q8WW43, Q92542, Q96BI3, Q9NZ42] | ||||||||
ChEMBL | Inhibition of gamma-secretase (unknown origin) | B | 4.4 | pIC50 | 40000 | nM | IC50 | Eur J Med Chem (2018) 148: 436-452 [PMID:29477076] |
GtoPdb | - | - | 4.4 | pEC50 | 40000 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 7277-80 [PMID:22061640] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]