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ChEMBL ligand: CHEMBL834 (CGP-23339AE, Pamidronate, Pamidronic acid, Pamidronic Acid, Ribodroat) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 6.48 | pKi | 331.4 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 7.25 | pKi | 55.9 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 5.71 | pIC50 | 1932 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase was determined | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) | B | 5.73 | pIC50 | 1862.09 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 6.45 | pIC50 | 353.2 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
ChEMBL | Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2002) 45: 2185-2196 [PMID:12014956] |
ChEMBL | Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2011) 54: 5955-5980 [PMID:21780776] |
GtoPdb | Inhibition of recombinant human FDPS expressed in E. coli. | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] | ||||||||
ChEMBL | Binding affinity towards Farnesyl diphosphate synthase from leishmania major | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (2005) 48: 2957-2963 [PMID:15828834] |
Hypoxanthine-guanine phosphoribosyltransferase in Trypanosoma brucei brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5069] [UniProtKB: Q07010] | ||||||||
ChEMBL | Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT) | B | 4.3 | pKi | 50600 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 4501-4504 [PMID:15357980] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]