ChEMBL ligand: CHEMBL834 (Acide pamidronique, Acido pamidronico, CGP-23339AE, Pamidronate, Pamidronic acid, Pamidronic Acid, Ribodroat)
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] There should be some charts here, you may need to enable JavaScript!
Hypoxanthine-guanine phosphoribosyltransferase in Trypanosoma brucei brucei [ChEMBL: CHEMBL5069] [UniProtKB: Q07010] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	6.48	pKi	331.4	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	6.74	pKi	180	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	7.25	pKi	55.9	nM	Ki	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21	B	5.71	pIC50	1932	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	5.72	pIC50	1900	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	5.73	pIC50	1862.09	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibition of human recombinant FPP synthase expressed in Escherichia coli S100 using FPP and IPP as substrates preincubated for 15 mins followed by substrate addition measured after 60 mins by scintillation counting analysis	B	6.3	pIC50	500	nM	IC50	J Med Chem (2021) 64: 9677-9710 [PMID:34236862]
ChEMBL	Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins	B	6.45	pIC50	353.2	nM	IC50	J Med Chem (2008) 51: 2187-2195 [PMID:18327899]
ChEMBL	Inhibitory activity against the human recombinant FPPSase (Farnesyl diphosphate) enzyme	B	6.7	pIC50	200	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
ChEMBL	Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation counting	B	6.7	pIC50	200	nM	IC50	J Med Chem (2011) 54: 5955-5980 [PMID:21780776]
GtoPdb	Inhibition of recombinant human FDPS expressed in E. coli.	-	6.7	pIC50	200	nM	IC50	J Med Chem (2008) 51: 2187-95 [PMID:18327899]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL	Binding affinity towards Farnesyl diphosphate synthase from leishmania major	B	6.72	pKi	190	nM	Ki	J Med Chem (2005) 48: 2957-2963 [PMID:15828834]
Hypoxanthine-guanine phosphoribosyltransferase in Trypanosoma brucei brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5069] [UniProtKB: Q07010]
ChEMBL	Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT)	B	4.3	pKi	50600	nM	Ki	Bioorg Med Chem Lett (2004) 14: 4501-4504 [PMID:15357980]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]