ChEMBL ligand: CHEMBL1200374 (Aromasin, Exemestane, Exemestano, FCE-24304, FCE24304, NSC-758907, PNU-155971)
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Irreversible inhibition of human aromatase extracted from placental microsomes	B	7.59	pKi	26	nM	Ki	Eur J Med Chem (2015) 105: 1-38 [PMID:26469743]
ChEMBL	Competitive inhibition of human placental microsome aromatase using varying levels of [1beta2beta3H]-androstenedione as substrate	B	7.59	pKi	26	nM	Ki	J Med Chem (2019) 62: 3636-3657 [PMID:30852901]
ChEMBL	Inhibition of human placental microsome aromatase using [3H]androstenedione as substrate preincubated for 32 mins in presence of NADPH followed by substrate addition and measured after 10 mins	B	7.59	pKi	26	nM	Ki	J Med Chem (2020) 63: 4824-4836 [PMID:32302132]
GtoPdb	-	-	7.6	pKi	-	-	-	J Steroid Biochem (1988) 30: 391-4 [PMID:3386266]
ChEMBL	Competitive inhibition of human aromatase extracted from placental microsomes	B	7.99	pKi	10.2	nM	Ki	Eur J Med Chem (2015) 105: 1-38 [PMID:26469743]
ChEMBL	Binding affinity to aromatase (unknown origin) assessed as inhibition constant	B	9.02	pKi	0.95	nM	Ki	Eur J Med Chem (2020) 208: 112845-112845 [PMID:33017749]
ChEMBL	Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid scintillation counting	B	6.05	pIC50	900	nM	IC50	Eur J Med Chem (2014) 87: 336-345 [PMID:25277066]
ChEMBL	Inhibition of aromatase (unknown origin)	B	6.64	pIC50	230	nM	IC50	Eur J Med Chem (2015) 105: 1-38 [PMID:26469743]
ChEMBL	Inhibition of human placental aromatase using [3H]-1beta-androstenedione as substrate after 16 hrs by [3H]-water method	B	7.3	pIC50	50.1	nM	IC50	J Med Chem (2012) 55: 8464-8476 [PMID:22951074]
ChEMBL	Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assay	B	7.3	pIC50	50.1	nM	IC50	Eur J Med Chem (2022) 240: 114569-114569 [PMID:35834906]
ChEMBL	Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation counting	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2014) 87: 336-345 [PMID:25277066]
ChEMBL	Inhibition of CYP19 in human placental microsome using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintillation counter method	B	7.37	pIC50	42.5	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2645-2649 [PMID:28512028]
GtoPdb	-	-	7.4	pIC50	50.1	nM	IC50	J Steroid Biochem (1988) 30: 391-4 [PMID:3386266]
ChEMBL	Inhibition of aromatase (unknown origin)	B	7.64	pIC50	23	nM	IC50	J Nat Prod (2021) 84: 1738-1747 [PMID:34110821]
ChEMBL	Inhibition of aromatase in human breast tumor	B	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2022) 241: 114658-114658 [PMID:35964426]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]