valproic acid [Ligand Id: 7009] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL109 (44089, Acide valproique, Acido valproico, Convulex, Depakene, Depakote, NSC-93819, Pentanoic acid, 2-propyl, Stavzor, Valproate, Valproic acid, Valproic acid extended release) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550] | ||||||||
| ChEMBL | Inhibition of AK1A1 | B | 4.3 | pIC50 | 50100 | nM | IC50 | J Med Chem (2010) 53: 7756-7766 [PMID:20936791] |
| Aldehyde reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3871] [UniProtKB: P51635] | ||||||||
| ChEMBL | Inhibition of Fischer-344 rat kidney AK1A1 | B | 4.25 | pIC50 | 56100 | nM | IC50 | J Med Chem (2010) 53: 7756-7766 [PMID:20936791] |
| ChEMBL | Inhibition of rat kidney aldehyde reductase at 0.1 mM after 20 mins by spectrometric analysis | B | 4.3 | pIC50 | 50100 | nM | IC50 | Bioorg Med Chem (2010) 18: 2107-2114 [PMID:20189816] |
| Aldose reductase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3081] [UniProtKB: P16116] | ||||||||
| ChEMBL | Inhibition of ALR1 in calf kidney using sodium D-glucoronate as substrate treated with compound for 10 mins prior to substrate addition by UV spectrophotometer analysis | B | 4.24 | pIC50 | 57400 | nM | IC50 | Eur J Med Chem (2015) 98: 127-138 [PMID:26005026] |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of Fischer-344 rat kidney ALR1 using D,L-glyceraldehyde as substrate by spectrophotometry | B | 4.25 | pIC50 | 56100 | nM | IC50 | Bioorg Med Chem (2013) 21: 869-873 [PMID:23312612] |
| ChEMBL | Inhibition of Fischer-344 rat kidney ALR1 using D-glucuronate as substrate by spectrophotometry | B | 4.25 | pIC50 | 56100 | nM | IC50 | Bioorg Med Chem (2014) 22: 2194-2207 [PMID:24630695] |
| ChEMBL | Inhibition of ALR1 in Wistar rat kidney assessed as reduction in NADPH consumption preincubated for 1 min followed by substrate addition measured after 4 mins by spectrophotometric analysis | B | 4.25 | pIC50 | 56100 | nM | IC50 | Bioorg Med Chem (2017) 25: 6353-6360 [PMID:29074349] |
| Aldose reductase-related protein 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421523] [UniProtKB: Q5RJP0] | ||||||||
| ChEMBL | Inhibition of Wistar rat kidney aldehyde reductase using D-glucuronate as substrate by spectrophotometry | B | 4.25 | pIC50 | 56100 | nM | IC50 | J Med Chem (2015) 58: 2649-2657 [PMID:25695864] |
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| GtoPdb | - | - | 3.4 | pIC50 | 400000 | nM | IC50 | J Biol Chem (2001) 276: 36734-41 [PMID:11473107] |
| ChEMBL | Inhibition of human full-length recombinant HDAC1 preincubated for 5 mins followed by HDAC substrate addition and further incubated for 45 mins by fluorescence microplate reader assay | B | 4.07 | pIC50 | 84210 | nM | IC50 | Eur J Med Chem (2021) 222: 113569-113569 [PMID:34111829] |
| ChEMBL | Inhibition of HADC1 (unknown origin) | B | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2020) 63: 23-39 [PMID:31415174] |
| ChEMBL | Inhibition of human recombinant HDAC1 using fluorogenic substrate | B | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2022) 65: 3080-3097 [PMID:35148101] |
| ChEMBL | Inhibition of human recombinant HDAC1 | B | 4.41 | pIC50 | 39000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC2 | B | 4.21 | pIC50 | 62000 | nM | IC50 | ACS Med Chem Lett (2011) 2: 39-42 [PMID:21874153] |
| sirtuin 5/NAD-dependent protein deacylase sirtuin-5, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163183] [GtoPdb: 2711] [UniProtKB: Q9NXA8] | ||||||||
| ChEMBL | Inhibition of SIRT5 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2012) 55: 5582-5590 [PMID:22583019] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum | F | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2017) 60: 4780-4804 [PMID:28241112] |
| Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] | ||||||||
| ChEMBL | Displacement of [3H]-pentazocine from sigma1 receptor in guinea pig brain membranes by scintillation counting | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2016) 59: 9960-9966 [PMID:27739690] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
