ChEMBL ligand: CHEMBL520733 (LY-450139, LY450139, Semagacestat)
presenilin 1/presenilin 2/Gamma-secretase in Human [ChEMBL: CHEMBL2094135] [GtoPdb: 2402, 2403] [UniProtKB: P49768, P49810, Q8WW43, Q92542, Q96BI3, Q9NZ42] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
presenilin 1/presenilin 2/Gamma-secretase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094135] [GtoPdb: 2402, 2403] [UniProtKB: P49768, P49810, Q8WW43, Q92542, Q96BI3, Q9NZ42]
ChEMBL	Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as effect on Abeta40 level after 24 hrs by DELFIA	B	6.7	pIC50	199.53	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1306-1311 [PMID:20056541]
ChEMBL	Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in Abeta42 level after 24 hrs by DELFIA	B	6.9	pIC50	125.89	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1306-1311 [PMID:20056541]
ChEMBL	Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as decrease in total Abeta level after 24 hrs by DELFIA	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1306-1311 [PMID:20056541]
ChEMBL	Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta40 formation by ELISA	B	7.4	pIC50	39.81	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1306-1311 [PMID:20056541]
ChEMBL	Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as amyloid beta42 formation by ELISA	B	7.4	pIC50	39.81	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1306-1311 [PMID:20056541]
ChEMBL	Inhibition of gamma secretase-mediated amyloid beta (1 to 40) production in human SH-SY5Y cells	B	7.42	pIC50	38	nM	IC50	J Med Chem (2009) 52: 6169-6188 [PMID:19694467]
ChEMBL	Displacement of [3H]5-chloro-N-((2S,3R)-5,5,5-trifluoro-1-hydroxy-3-methylpentan-2-yl)thiophene-2-sulfonamide from gamma secretase in human SH-SY5Y cells by competitive binding assay	B	7.42	pIC50	38	nM	IC50	J Med Chem (2009) 52: 6169-6188 [PMID:19694467]
GtoPdb	-	-	7.82	pIC50	15	nM	IC50	J Med Chem (2009) 52: 6169-88 [PMID:19694467]
ChEMBL	Inhibition of gamma secretase (unknown origin) mediated Notch signaling	B	7.85	pIC50	14.1	nM	IC50	J Med Chem (2016) 59: 7719-7737 [PMID:27045975]
ChEMBL	Inhibition of gamma secretase (unknown origin)	B	7.96	pIC50	10.9	nM	IC50	J Med Chem (2016) 59: 7719-7737 [PMID:27045975]
ChEMBL	Inhibition of partially purified human gamma-secretase-mediated cleavage of MBP-APPc125Sw fusion protein measured after overnight incubation by ELISA	B	8.1	pIC50	7.9	nM	IC50	J Med Chem (2013) 56: 5261-5274 [PMID:23713656]
ChEMBL	Inhibition of partially purified human gamma-secretase-mediated cleavage of notch fusion protein measured after overnight incubation by ELISA	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2013) 56: 5261-5274 [PMID:23713656]
ChEMBL	Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant APP assessed as increase in Abeta38 level after 24 hrs by DELFIA	B	6.9	pEC50	125.89	nM	EC50	Bioorg Med Chem Lett (2010) 20: 1306-1311 [PMID:20056541]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]