azilsartan [Ligand Id: 6901] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL57242 (Azilsartan, TAK-536)
  • Angiotensin II type 1a (AT-1a) receptor in Bovine [ChEMBL: CHEMBL3374] [UniProtKB: P25104]
Created with Highcharts 10.3.3ValuesChart context menuAngiotensin II type 1a (AT-1a) receptorpKd BovinepKi BovinepIC50 BovinepEC50 Bovine02468Highcharts.com
  • AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
Created with Highcharts 10.3.3ValuesChart context menuAT1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin II type 1a (AT-1a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3374] [UniProtKB: P25104]
ChEMBL Displacement of [125 I]-AII (0.2 nM) from bovine adrenal cortical membrane angiotensin II (AII) receptor at 10e-7 M B 6.38 pIC50 420 nM IC50 Bioorg Med Chem Lett (1995) 5: 1903-1908
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb - - 8.13 pIC50 7.4 nM IC50 Clin Ther (2014) 36: 711-21 [PMID:24742498];
Hypertens Res (2014) 37: 852-7 [PMID:24739538]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]