forasartan [Ligand Id: 6896] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL315021 (Forasartan, SC-52458) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Antagonist activity at angiotensin AT1 receptor | F | 8.2 | pKd | 6.31 | nM | Kd | Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232] |
| ChEMBL | Binding affinity to angiotensin AT1 receptor | B | 8.16 | pIC50 | 6.9 | nM | IC50 | Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232] |
| AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089, P25095] | ||||||||
| GtoPdb | - | - | 8.6 | pIC50 | 2.8 | nM | IC50 | J Cardiovasc Pharmacol (1993) 22: 617-25 [PMID:7505365] |
| AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] | ||||||||
| ChEMBL | Binding affinity for rat angiotensin II receptor, type 1 | B | 8.16 | pIC50 | 6.9 | nM | IC50 | J Med Chem (2004) 47: 2574-2586 [PMID:15115399] |
| GtoPdb | - | - | 8.6 | pIC50 | 2.8 | nM | IC50 | J Cardiovasc Pharmacol (1993) 22: 617-25 [PMID:7505365] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
