ChEMBL ligand: CHEMBL1643 (Copegus, Cotronak, NSC-163039, Rebetol, Ribapak, Ribasphere, Ribavarin, Ribavirin, Ribavirina, Ribavirin biopartners, Ribavirine, Ribavirin mylan, Ribavirin teva, Ribofluranosyl Carboxamide, SCH 18908, SCH-18908, Tribavirin, Viramid, Virazid, Virazole)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] A1 receptor/Adenosine A1 receptor in Mouse [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612] There should be some charts here, you may need to enable JavaScript!
DNA topoisomerase I in Human [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] There should be some charts here, you may need to enable JavaScript!
Eukaryotic translation initation factor in Human [ChEMBL: CHEMBL4848] [UniProtKB: P06730] There should be some charts here, you may need to enable JavaScript!
Genome polyprotein in Enterovirus A71 [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478] There should be some charts here, you may need to enable JavaScript!
NS5 in Zika virus [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
RNA-directed RNA polymerase in Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) [ChEMBL: CHEMBL4523676] [UniProtKB: P03428, P03431, P03433] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	5.13	pKi	7410	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
ChEMBL	Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	5.35	pKi	4430	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL	Inhibition of human topoisomerase 1 activity assessed as DNA triplex formation and presence of supercoiled DNA by microplate assay	B	4.18	pIC50	65880	nM	IC50	Medchemcomm (2013) 4: 278-288
Eukaryotic translation initation factor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4848] [UniProtKB: P06730]
ChEMBL	Binding affinity to eIF4E (unknown origin) assessed as dissociation constant	B	5.08	pKd	8400	nM	Kd	RSC Med Chem (2023) 14: 1060-1087 [PMID:37360400]
Genome polyprotein in Enterovirus A71 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478]
ChEMBL	Inhibition of Enterovirus 71 Shenzhen/120F1/09 capsid infected in human RD cells assessed as reduction in virus-induced cell death after 72 hrs by CCK-8 assay	B	4	pEC50	>100000	nM	EC50	ACS Med Chem Lett (2017) 8: 841-846 [PMID:28835799]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL	Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity after 72 hrs by DAPI staining based assay	B	4.68	pEC50	20800	nM	EC50	J Med Chem (2020) 63: 470-489 [PMID:31549836]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
RNA-directed RNA polymerase in Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4523676] [UniProtKB: P03428, P03431, P03433]
ChEMBL	Inhibition of RdRP activity in Influenza A virus A/PR/8/34 (H1N1) infected in HEK293T cells co-transfected with NP/PA/PB1/PB2/pPolI-Flu-ffLuc/pRL-SV40 incubated for 24 hrs by minireplicon based dual luciferase assay	B	4.62	pEC50	24000	nM	EC50	Eur J Med Chem (2021) 209: 112944-112944 [PMID:33328103]
ChEMBL	Inhibition of RdRP activity in Influenza A virus A/PR/8/34(H1N1) infected in HEK293T cells incubated for 24 hrs by minireplicon based dual luciferase assay	B	4.8	pEC50	16000	nM	EC50	Eur J Med Chem (2021) 221: 113494-113494 [PMID:33962311]
inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839]
GtoPdb	In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed)	-	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]
inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268]
GtoPdb	In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed)	-	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]