ChEMBL ligand: CHEMBL1643 (Copegus, Cotronak, NSC-163039, Rebetol, Ribapak, Ribasphere, Ribavarin, Ribavirin, Ribavirin biopartners, Ribavirin mylan, Ribavirin teva, Ribofluranosyl Carboxamide, SCH 18908, SCH-18908, Tribavirin, Viramid, Virazid, Virazole)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] A1 receptor/Adenosine A1 receptor in Mouse [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612] There should be some charts here, you may need to enable JavaScript!
DNA topoisomerase I in Human [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] There should be some charts here, you may need to enable JavaScript!
Genome polyprotein in Enterovirus A71 [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478] There should be some charts here, you may need to enable JavaScript!
NS5 in Zika virus [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
RNA-directed RNA polymerase in Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) [ChEMBL: CHEMBL4523676] [UniProtKB: P03428, P03431, P03433] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839] There should be some charts here, you may need to enable JavaScript!
inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	5.13	pKi	7410	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
A1 receptor/Adenosine A1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3688] [GtoPdb: 18] [UniProtKB: Q60612]
ChEMBL	Displacement of [3H]N6-R-phenylisopropyladenosine from mouse A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation proximity assay	B	5.35	pKi	4430	nM	Ki	J Med Chem (2019) 62: 1502-1522 [PMID:30605331]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL	Inhibition of human topoisomerase 1 activity assessed as DNA triplex formation and presence of supercoiled DNA by microplate assay	B	4.18	pIC50	65880	nM	IC50	Medchemcomm (2013) 4: 278-288
Genome polyprotein in Enterovirus A71 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295606] [UniProtKB: Q66478]
ChEMBL	Inhibition of Enterovirus 71 Shenzhen/120F1/09 capsid infected in human RD cells assessed as reduction in virus-induced cell death after 72 hrs by CCK-8 assay	B	4	pEC50	>100000	nM	EC50	ACS Med Chem Lett (2017) 8: 841-846 [PMID:28835799]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL	Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity after 72 hrs by DAPI staining based assay	B	4.68	pEC50	20800	nM	EC50	J Med Chem (2020) 63: 470-489 [PMID:31549836]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
RNA-directed RNA polymerase in Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4523676] [UniProtKB: P03428, P03431, P03433]
ChEMBL	Inhibition of RdRP activity in Influenza A virus A/PR/8/34 (H1N1) infected in HEK293T cells co-transfected with NP/PA/PB1/PB2/pPolI-Flu-ffLuc/pRL-SV40 incubated for 24 hrs by minireplicon based dual luciferase assay	B	4.62	pEC50	24000	nM	EC50	Eur J Med Chem (2021) 209: 112944-112944 [PMID:33328103]
ChEMBL	Inhibition of RdRP activity in Influenza A virus A/PR/8/34(H1N1) infected in HEK293T cells incubated for 24 hrs by minireplicon based dual luciferase assay	B	4.8	pEC50	16000	nM	EC50	Eur J Med Chem (2021) 221: 113494-113494 [PMID:33962311]
inosine monophosphate dehydrogenase 1 in Human [GtoPdb: 2624] [UniProtKB: P20839]
GtoPdb	In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed)	-	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]
inosine monophosphate dehydrogenase 2 in Human [GtoPdb: 2625] [UniProtKB: P12268]
GtoPdb	In vitro inhibition of IMPDH (isoform not specified, human and mouse assayed)	-	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2012) 20: 3675-85 [PMID:22555152]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]