repaglinide [Ligand Id: 6841] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1272 (A10BX02, AG-EE 623 ZW, AG-EE-623-ZW, AG-EE-623ZW, AGEE-623ZW, Enyglid, Novonorm, NSC-759893, Prandin, Repaglinida, Repaglinide, Repaglinide krka) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
| ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 5.04 | pIC50 | 9200 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 8/Sulfonylurea receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2071] [GtoPdb: 2594] [UniProtKB: Q09428] | ||||||||
| ChEMBL | Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) | B | 7.3 | pKd | 50 | nM | Kd | Bioorg Med Chem Lett (2004) 14: 5205-5209 [PMID:15380228] |
| GtoPdb | - | - | 6.97 | pIC50 | 106 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5205-9 [PMID:15380228] |
| ChEMBL | In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) | B | 6.97 | pIC50 | 106 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5205-5209 [PMID:15380228] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
