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ChEMBL ligand: CHEMBL866 (68618, Mycophenolate, Mycophenolate mofetil impurity, mycophenolic acid-, Mycophenolic acid, Myfortic, NSC-129185, RS-61443 [AS MOFETIL]) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Inosine-5`-monophosphate dehydrogenase in Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /ATCC MYA-565) (Filobasidiella neoformans) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295605] [UniProtKB: Q5KP44] | ||||||||
ChEMBL | Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754] |
inosine monophosphate dehydrogenase 1/Inosine-5`-monophosphate dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1822] [GtoPdb: 2624] [UniProtKB: P20839] | ||||||||
ChEMBL | Inhibition of human IMPDH 1 | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2007) 50: 6685-6691 [PMID:18038969] |
ChEMBL | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I) | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2002) 45: 703-712 [PMID:11806722] |
ChEMBL | Inhibition of human IMPDH1 | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2008) 16: 9340-9345 [PMID:18809333] |
ChEMBL | Inhibition of human IMP dehydrogenase 1 | B | 7.4 | pKi | 40 | nM | Ki | Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139] |
ChEMBL | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nM | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (1998) 41: 618-622 [PMID:9484510] |
ChEMBL | Inhibition of human IMPDH type 1 | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2007) 50: 5743-5751 [PMID:17958343] |
ChEMBL | Inhibition of human IMPDH1 by Spectrophotometry | B | 7.48 | pKi | 33 | nM | Ki | Bioorg Med Chem (2011) 19: 1594-1605 [PMID:21324702] |
ChEMBL | Inhibition of recombinant human His-tagged IMPDH1 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754] |
ChEMBL | Inhibitory activity against inosine monophosphate dehydrogenase IMPDH type I | B | 7.26 | pIC50 | 55 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 543-546 [PMID:12565968] |
ChEMBL | Inhibition of human IMPDH1 | B | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3479-3483 [PMID:16621550] |
ChEMBL | In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1990) 33: 833-838 [PMID:1967654] |
GtoPdb | Reference does not distinguish which enzyme isoform is assayed | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1990) 33: 833-8 [PMID:1967654] |
ChEMBL | Inhibition of human IMPDH1 expressed in Escherichia coli strain BL21(DE3) after 60 mins | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem (2010) 18: 8106-8111 [PMID:20934342] |
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] | ||||||||
ChEMBL | Inhibition of human IMPDH 2 | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2007) 50: 6685-6691 [PMID:18038969] |
ChEMBL | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2002) 45: 703-712 [PMID:11806722] |
ChEMBL | Inhibition of human IMPDH2 | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem (2008) 16: 9340-9345 [PMID:18809333] |
ChEMBL | Inhibition of human IMP dehydrogenase 2 | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem (2008) 16: 7462-7469 [PMID:18583139] |
ChEMBL | Inhibition of human IMPDH type 2 | B | 8.15 | pKi | 7 | nM | Ki | J Med Chem (2007) 50: 5743-5751 [PMID:17958343] |
ChEMBL | Inhibition of human IMPDH2 by Spectrophotometer | B | 8.15 | pKi | 7 | nM | Ki | Bioorg Med Chem (2011) 19: 1594-1605 [PMID:21324702] |
ChEMBL | Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nM | B | 8.22 | pKi | 6 | nM | Ki | J Med Chem (1998) 41: 618-622 [PMID:9484510] |
ChEMBL | Inhibition of IMPDH2 | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 53-56 [PMID:22172700] |
ChEMBL | Inhibition of IMPDH2 using inosine 5'-monophosphate as substrate by spectrophotometry | B | 6.2 | pIC50 | 630 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3332-3335 [PMID:22464133] |
ChEMBL | Inhibition of human IMPDH2 using IMP as substrate in presence of NAD+ after 30 mins | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2018) 158: 286-301 [PMID:30223117] |
ChEMBL | Inhibition of recombinant human His-tagged IMPDH2 expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem (2018) 26: 5408-5419 [PMID:30322754] |
ChEMBL | Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 7.4 | B | 7.6 | pIC50 | 25.1 | nM | IC50 | J Med Chem (1996) 39: 4181-4196 [PMID:8863796] |
ChEMBL | Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 8.0 | B | 7.61 | pIC50 | 24.8 | nM | IC50 | J Med Chem (1996) 39: 4181-4196 [PMID:8863796] |
GtoPdb | Reference does not distinguish which enzyme isoform is assayed | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1990) 33: 833-8 [PMID:1967654] |
ChEMBL | Inhibition of human IMPDH2 | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2007) 50: 3730-3742 [PMID:17585753] |
ChEMBL | In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2. | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2931-2934 [PMID:12270177] |
ChEMBL | Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 3125-3128 [PMID:12372516] |
ChEMBL | Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3557-3560 [PMID:14505670] |
ChEMBL | Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 3305-3308 [PMID:12392738] |
ChEMBL | Inhibition of human Inosine-5'-monophosphate dehydrogenase 2 | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2137-2140 [PMID:12127522] |
ChEMBL | Inhibition of human inosine monophosphate dehydrogenase IMPDH II | B | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 543-546 [PMID:12565968] |
ChEMBL | Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II | B | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 547-551 [PMID:12565969] |
ChEMBL | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2002) 45: 2127-2130 [PMID:12014950] |
ChEMBL | Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 mins | B | 7.92 | pIC50 | 12 | nM | IC50 | Bioorg Med Chem (2010) 18: 8106-8111 [PMID:20934342] |
ChEMBL | Inhibition of human IMPDH2 | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3479-3483 [PMID:16621550] |
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells | F | 6 | pIC50 | 1000 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | HARVARD: Inhibition of blood stage Plasmodium falciparum Dd2 infection | F | 5.3 | pIC50 | >5000 | nM | IC50 | Proc Natl Acad Sci U S A (2012) 109: 8511-8516 [PMID:22586124] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]