ChEMBL ligand: CHEMBL1164729 (Adenuric, Febuxostat, Febuxostat mylan, NSC-758874, TMX-67, Uloric)
ABCG2/ATP-binding cassette sub-family G member 2 in Human [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] There should be some charts here, you may need to enable JavaScript!
Flavin reductase in Human [ChEMBL: CHEMBL5019] [UniProtKB: P30043] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] Xanthine dehydrogenase in Bovine [ChEMBL: CHEMBL3649] [UniProtKB: P80457] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase in Human [GtoPdb: 2646] [UniProtKB: P47989] xanthine dehydrogenase in Bovine [GtoPdb: 2646] xanthine dehydrogenase/Xanthine dehydrogenase/oxidase in Rat [ChEMBL: CHEMBL1075246] [GtoPdb: 2646] [UniProtKB: P22985] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0]
ChEMBL	Inhibition of ABCG2 (unknown origin) expressed in human HEK293-A cells membrane vesicles assessed inhibition of ABCG2-mediated urate transport activity by rapid filtration technique	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2022) 237: 114346-114346 [PMID:35483322]
Flavin reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5019] [UniProtKB: P30043]
ChEMBL	Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry	B	5.79	pKd	1630	nM	Kd	J Med Chem (2022) 65: 2548-2557 [PMID:34957824]
ChEMBL	Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry	B	5.79	pKd	1621.81	nM	Kd	J Med Chem (2022) 65: 2548-2557 [PMID:34957824]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	7.26	pIC50	55.42	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL	Inhibition of xanthine dehydrogenase (unknown origin)	B	8.51	pKi	3.1	nM	Ki	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	Inhibition of xanthine oxidase (unknown origin)	B	9.22	pKi	0.6	nM	Ki	Eur J Med Chem (2019) 166: 186-196 [PMID:30769179]
ChEMBL	Non-competitive inhibition of human xanthine oxidase	B	10	pKi	0.1	nM	Ki	Eur J Med Chem (2017) 135: 491-516 [PMID:28478180]
ChEMBL	Mixed-type inhibition of xanthine oxidase (unknown origin) assessed as inhibitory constant of enzyme-substrate complex using xanthine as substrate at varying concentrations preincubated for 15 mins followed by substrate addition by UV spectrophotometric analysis	B	10	pKi	0.1	nM	Ki	Eur J Med Chem (2022) 229: 114086-114086 [PMID:34992040]
ChEMBL	Inhibition of XO (unknown origin)	B	4.6	pIC50	25000	nM	IC50	Eur J Med Chem (2023) 245: 114890-114890 [PMID:36335742]
ChEMBL	Inhibition of XOD (unknown origin) using xanthine as substrate preincubated for 30 mins followed by xanthine addition measured after 30 mins by microplate reader	B	6.8	pIC50	160	nM	IC50	J Nat Prod (2023) 86: 2091-2101 [PMID:37625387]
ChEMBL	Inhibition of xanthine oxidase using xanthine as substrate at 30 mins by spectrophotometric analysis	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7543-7546 [PMID:23122864]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 15 mins followed by substrate addition by UV spectrophotometric analysis	B	7.55	pIC50	28	nM	IC50	Eur J Med Chem (2022) 229: 114086-114086 [PMID:34992040]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate incubated for 15 mins followed by substrate addition by spectrophotometric analysis	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2022) 227: 113928-113928 [PMID:34688012]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 5 mins followed by substrate addition measured for 20 mins by spectrophotometric method	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2018) 155: 590-595 [PMID:29920453]
ChEMBL	Inhibition of XOR (unknown origin) using xanthine as substrate incubated for 3 mins followed by xanthine addition by spectroscopy based analysis	B	8.16	pIC50	6.91	nM	IC50	Eur J Med Chem (2023) 246: 114947-114947 [PMID:36462435]
ChEMBL	Inhibition of xanthine oxidase (unknown origin) measured by spectrophotometric analysis	B	8.53	pIC50	2.92	nM	IC50	Eur J Med Chem (2022) 230: 114101-114101 [PMID:35063733]
ChEMBL	Inhibition of C-terminally FLAG-tagged human xanthine oxidase (amino acid 1 to 1333) expressed in baculovirus system after 15 mins by spectrophotometry	B	8.9	pIC50	1.26	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1315-1321 [PMID:24508129]
GtoPdb	Inhibition of baculovirus expressed C-terminally FLAG-tagged human xanthine oxidase (aa 1-1333).	-	8.9	pIC50	1.26	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1315-21 [PMID:24508129]
Xanthine dehydrogenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3649] [UniProtKB: P80457]
ChEMBL	Binding affinity to bovine milk XO using xanthine as substrate assessed as inhibition constant by 1/V-axis intercept replot based method	B	8.51	pKi	3.1	nM	Ki	Eur J Med Chem (2023) 250: 115172-115172 [PMID:36758304]
ChEMBL	Mixed-type inhibition of bovine xanthine oxidase assessed as enzyme-inhibitor complex	B	9.05	pKi	0.9	nM	Ki	J Nat Prod (2014) 77: 1693-1699 [PMID:25060641]
ChEMBL	Binding affinity to bovine milk XO using xanthine as substrate assessed as inhibition constant by Dixon plot based method	B	9.22	pKi	0.6	nM	Ki	Eur J Med Chem (2023) 250: 115172-115172 [PMID:36758304]
ChEMBL	Mixed-type inhibition of bovine xanthine oxidase	B	9.92	pKi	0.12	nM	Ki	J Nat Prod (2014) 77: 1693-1699 [PMID:25060641]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 5 mins followed by substrate addition by UV-visible spectrophotometry	B	7.52	pIC50	30	nM	IC50	Medchemcomm (2019) 10: 128-147 [PMID:30931089]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate assessed as decrease in uric acid formation preincubated for 5 mins	B	7.6	pIC50	25	nM	IC50	Bioorg Med Chem Lett (2014) 24: 495-500 [PMID:24388807]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate incubated for 15 mins followed by substrate addition and measured at 30 sec interval for 2 mins by spectrophotometrically	B	7.63	pIC50	23.6	nM	IC50	Eur J Med Chem (2019) 181: 111559-111559 [PMID:31376568]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured every 30 secs for 2 mins by spectrophotometric method	B	7.63	pIC50	23.6	nM	IC50	Eur J Med Chem (2019) 181: 111558-111558 [PMID:31369933]
ChEMBL	Inhibition of bovine xanthine oxidase-mediated uric acid production after 30 mins by spectrophotometric analysis	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2013) 23: 834-838 [PMID:23265878]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 15 mins followed by substrate addition measured at 30 sec interval for upto 2 mins by spectrophotometric analysis	B	7.72	pIC50	18.9	nM	IC50	J Med Chem (2020) 63: 15752-15772 [PMID:33307675]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as inhibition of uric acid formation after 30 mins by spectrophotometry	B	7.73	pIC50	18.6	nM	IC50	Eur J Med Chem (2014) 85: 508-516 [PMID:25113879]
ChEMBL	Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 15 mins followed by substrate addition measured for every 30 sec by spectrophotometric analysis	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2021) 38: 116117-116117 [PMID:33838610]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation preincubated for 5 mins followed by xanthine addition and measured after 20 mins by spectrophotometry	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2019) 27: 1818-1823 [PMID:30885567]
ChEMBL	Inhibition of bovine milk xanthine-oxidase using xanthine as substrate after 5 mins by spectrophotometric method	B	8	pIC50	10	nM	IC50	Bioorg Med Chem (2017) 25: 3606-3613 [PMID:28545814]
ChEMBL	Inhibition of bovine XO using xanthine as substrate after 120 mins by spectrophotometric analysis	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2015) 103: 343-353 [PMID:26363870]
ChEMBL	Inhibition of bovine XO using xanthine as substrate after 120 mins by spectrophotometric analysis	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2015) 103: 343-353 [PMID:26363870]
ChEMBL	Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate incubated for 3 mins by microplate assay	B	8.15	pIC50	7	nM	IC50	Eur J Med Chem (2020) 186: 111883-111883 [PMID:31761385]
ChEMBL	Inhibition of bovine milk xanthine oxidoreductase pre-incubated for 3 mins followed xanthine substrate addition and measured every 1 mins for 10 mins by spectrophotometry	B	8.28	pIC50	5.2	nM	IC50	Eur J Med Chem (2017) 140: 20-30 [PMID:28918097]
ChEMBL	Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 3 mins followed by substrate addition and measured at 1 min for 10 mins	B	8.32	pIC50	4.8	nM	IC50	Bioorg Med Chem Lett (2019) 29: 525-528 [PMID:30630716]
ChEMBL	Inhibition of bovine xanthine oxidase by spectrophotometry	B	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2010) 45: 2663-2670 [PMID:20189693]
ChEMBL	Inhibition of Bovine milk XO using xanthine as substrate assessed as decrease in uric acid level measured after 30 mins by microplate reader analysis	B	8.56	pIC50	2.78	nM	IC50	RSC Med Chem (2023) 14: 2155-2191 [PMID:37974965]
xanthine dehydrogenase in Human [GtoPdb: 2646] [UniProtKB: P47989]
GtoPdb	Inhibition of baculovirus expressed C-terminally FLAG-tagged human xanthine oxidase (aa 1-1333).	-	8.9	pIC50	1.26	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1315-21 [PMID:24508129]
xanthine dehydrogenase in Bovine [GtoPdb: 2646]
GtoPdb	In vitro assay using purified bovine enzyme	-	9.92	pKi	0.12	nM	Ki	J Biol Chem (2003) 278: 1848-55 [PMID:12421831]
GtoPdb	In vitro assay using purified bovine enzyme	-	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2012) 22: 7543-6 [PMID:23122864]
xanthine dehydrogenase/Xanthine dehydrogenase/oxidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075246] [GtoPdb: 2646] [UniProtKB: P22985]
ChEMBL	Inhibition of rat xanthine oxidase	B	8.4	pIC50	3.98	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1315-1321 [PMID:24508129]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]