ChEMBL ligand: CHEMBL1138 (Ezetimiba, Ezetimibe, Ezetrol, MK0653, NSC-758923, SCH-58235, SCH58235, Zetia)
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9] NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Rat [ChEMBL: CHEMBL5161] [GtoPdb: 2629] [UniProtKB: Q6T3U3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
ChEMBL	Binding affinity to NTCP (unknown origin)	B	4.6	pKi	25000	nM	Ki	J Med Chem (2022) 65: 12546-12561 [PMID:36111355]
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9]
GtoPdb	Measure of ezetimibe glucuronide binding to NPC1L1	-	6.66	pKd	220	nM	Kd	Proc Natl Acad Sci USA (2005) 102: 8132-7 [PMID:15928087]
ChEMBL	Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assay	B	6.43	pIC50	370	nM	IC50	Eur J Med Chem (2022) 230: 114111-114111 [PMID:35063734]
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5161] [GtoPdb: 2629] [UniProtKB: Q6T3U3]
ChEMBL	Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membrane	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2008) 18: 546-553 [PMID:18063367]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]