MRL20 [Ligand Id: 6742] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL181937 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | In vitro inhibition of human Peroxisome proliferator activated receptor gamma | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 357-362 [PMID:15603954] |
| GtoPdb | - | - | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 357-62 [PMID:15603954] |
| ChEMBL | In vitro maximal activation of human Peroxisome proliferator activated receptor gamma in COS-1 cell transactivation assay | F | 8.7 | pEC50 | 2 | nM | EC50 | Bioorg Med Chem Lett (2005) 15: 357-362 [PMID:15603954] |
| ChEMBL | Modulation of 6His-tagged PPARgamma isoform 1 LBD (203 to 477 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells assessed as increase in FITC-TRAP220 peptide recruitment after 1 to 4 hrs by TR-FRET assay | B | 8.7 | pEC50 | 2 | nM | EC50 | Eur J Med Chem (2019) 176: 326-342 [PMID:31112893] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
