ChEMBL ligand: CHEMBL573970
Acyl coenzyme A:cholesterol acyltransferase 1 in Rat [ChEMBL: CHEMBL285] [UniProtKB: O70536] There should be some charts here, you may need to enable JavaScript!
acetyl-CoA acetyltransferase 1 in Rat [GtoPdb: 2435] [UniProtKB: P17764] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acyl coenzyme A:cholesterol acyltransferase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL285] [UniProtKB: O70536]
ChEMBL	Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester after 24 hrs	B	7.51	pIC50	31	nM	IC50	Bioorg Med Chem (2009) 17: 4636-4646 [PMID:19464189]
acetyl-CoA acetyltransferase 1 in Rat [GtoPdb: 2435] [UniProtKB: P17764]
GtoPdb	-	-	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2006) 16: 44-8 [PMID:16242323]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]