Ro 48-8071 [Ligand Id: 6710] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL304858 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
| ChEMBL | Inhibition of oxidosqualene cyclase | B | 6.65 | pIC50 | 223.87 | nM | IC50 | Eur J Med Chem (2008) 43: 1462-1468 [PMID:17981368] |
| ChEMBL | Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR method | B | 8.12 | pIC50 | 7.5 | nM | IC50 | J Med Chem (2018) 61: 5047-5053 [PMID:29771525] |
| ChEMBL | Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes | B | 8.19 | pIC50 | 6.5 | nM | IC50 | J Med Chem (2003) 46: 2083-2092 [PMID:12747780] |
| ChEMBL | Inhibition of oxidosqualene cyclase | B | 8.19 | pIC50 | 6.46 | nM | IC50 | J Med Chem (2007) 50: 5039-5042 [PMID:17760433] |
| GtoPdb | - | - | 8.24 | pIC50 | 5.7 | nM | IC50 | J Med Chem (2012) 55: 4990-5002 [PMID:22533316] |
| Squalene-hopene cyclase in Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3569] [UniProtKB: P33247] | ||||||||
| ChEMBL | Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2003) 46: 2083-2092 [PMID:12747780] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
