ChEMBL ligand: CHEMBL304858
lanosterol synthase/Lanosterol synthase in Human [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] There should be some charts here, you may need to enable JavaScript!
Squalene-hopene cyclase in Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) [ChEMBL: CHEMBL3569] [UniProtKB: P33247] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449]
ChEMBL	Inhibition of oxidosqualene cyclase	B	6.65	pIC50	223.87	nM	IC50	Eur J Med Chem (2008) 43: 1462-1468 [PMID:17981368]
ChEMBL	Inhibition of human C-terminal His6-tagged OSC expressed in Pichia pastoris GS115 using 2,3-oxidosqualene as substrate after 90 mins by 1H NMR method	B	8.12	pIC50	7.5	nM	IC50	J Med Chem (2018) 61: 5047-5053 [PMID:29771525]
ChEMBL	Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes	B	8.19	pIC50	6.5	nM	IC50	J Med Chem (2003) 46: 2083-2092 [PMID:12747780]
ChEMBL	Inhibition of oxidosqualene cyclase	B	8.19	pIC50	6.46	nM	IC50	J Med Chem (2007) 50: 5039-5042 [PMID:17760433]
GtoPdb	-	-	8.24	pIC50	5.7	nM	IC50	J Med Chem (2012) 55: 4990-5002 [PMID:22533316]
Squalene-hopene cyclase in Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3569] [UniProtKB: P33247]
ChEMBL	Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius	B	7.22	pIC50	60	nM	IC50	J Med Chem (2003) 46: 2083-2092 [PMID:12747780]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]