compound 4b [Marquart et al., 1994] [Ligand Id: 6708] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL278521 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
| ChEMBL | Evaluated for its activity to inhibit rat liver 2,3-oxidosqualene-lanosterol cyclase, activity expressed as Ki | B | 6.96 | pKi | 110 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1317-1318 |
| ChEMBL | Concentration required to inhibit rat liver 2,3-oxidosqualene-lanosterol cyclase (OSC) | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1317-1318 |
| lanosterol synthase in Rat [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| GtoPdb | - | - | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1317-1318 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
