compound 4a [Marquart et al., 1994] [Ligand Id: 6707] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL277446 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
| ChEMBL | Evaluated for its activity to inhibit rat liver 2,3-oxidosqualene-lanosterol cyclase, activity expressed as Ki | B | 6.29 | pKi | 510 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 1317-1318 |
| ChEMBL | Concentration required to inhibit rat liver 2,3-oxidosqualene-lanosterol cyclase | B | 6.37 | pIC50 | 430 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1317-1318 |
| lanosterol synthase in Rat [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| GtoPdb | - | - | 6.37 | pIC50 | 430 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1317-1318 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
