galantamine [Ligand Id: 6693] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL659 (Acumor xl, Consion xl, Elmino xl, Galantamina, (-)-galantamine, Galantamine, (-)-galanthamine, Galanthamine, Galsya xl, Galzemic xl, Gatalin xl, Gazylan xl, Lotprosin xl, Luventa xl, NSC-100058, Razadyne, Reminyl, Reminyl xl, Zeebral xl) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
| ChEMBL | Inhibition of Torpedo californica AChE | B | 6.19 | pIC50 | 652 | nM | IC50 | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
| ChEMBL | Inhibition of Torpedo californica AchE activity by Ellman's assay | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem (2008) 16: 6560-6567 [PMID:18538575] |
| ChEMBL | Inhibition of AChE | B | 6.26 | pIC50 | 550 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2123-2125 [PMID:17317172] |
| ChEMBL | Inhibitory activity against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition) | B | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1825-1827 [PMID:12729674] |
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | B | 5.81 | pKi | 1560 | nM | Ki | J Med Chem (2005) 48: 8270-8288 [PMID:16366609] |
| ChEMBL | Competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method | B | 5.97 | pKi | 1060 | nM | Ki | J Med Chem (2013) 56: 2038-2044 [PMID:23330848] |
| ChEMBL | Binding affinity to electrical eel AChE assessed as inhibition constant incubated for 20 mins by absorbance based analysis | B | 6.3 | pKi | 500 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Inhibitory activity against AChE from electric eel | B | 6.36 | pKi | 440 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burke plot analysis | B | 6.37 | pKi | 428 | nM | Ki | Bioorg Med Chem (2010) 18: 5861-5872 [PMID:20656495] |
| ChEMBL | In vitro inhibitory activity against acetylcholinesterase (AChE) in Electrophorus electricus | B | 4.46 | pIC50 | 35000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2389-2391 [PMID:12824041] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured every 5 mins for 15 mins by spectrophotometric method | B | 4.66 | pIC50 | 21820 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2481-2484 [PMID:29887354] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured every 15 secs for 5 to 10 mins by Ellman's method | B | 4.9 | pIC50 | 12730 | nM | IC50 | Bioorg Med Chem (2016) 24: 5762-5770 [PMID:27681239] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4.98 | pIC50 | 10530 | nM | IC50 | Eur J Med Chem (2014) 76: 376-386 [PMID:24594525] |
| ChEMBL | Inhibition of electric eel AChE using ATC as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's assay | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem (2016) 24: 886-893 [PMID:26795115] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3368-3376 [PMID:28457693] |
| ChEMBL | Competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method | B | 5.13 | pIC50 | 7440 | nM | IC50 | J Med Chem (2013) 56: 2038-2044 [PMID:23330848] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate by Ellman's method | B | 5.35 | pIC50 | 4480 | nM | IC50 | Eur J Med Chem (2016) 124: 270-283 [PMID:27592396] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine as substrate after 10 mins by Ellman's method | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem (2013) 21: 1735-1748 [PMID:23462716] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate assessed as concentration of 5-thio-2-nitrobenzoic acid ion formed by spectrophotometric/Ellman's method | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Nat Prod (2015) 78: 1189-1192 [PMID:26030662] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 5.45 | pIC50 | 3580 | nM | IC50 | Eur J Med Chem (2019) 179: 680-693 [PMID:31280020] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 5.45 | pIC50 | 3570 | nM | IC50 | Eur J Med Chem (2017) 127: 671-690 [PMID:27823887] |
| ChEMBL | Inhibition of electric eel AChE preincubated for 6 mins followed by addition of acetylthiocholine iodide by Ellman's method | B | 5.45 | pIC50 | 3560 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3881-3885 [PMID:27426301] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6185-6187 [PMID:20850311] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2010) 18: 5071-5080 [PMID:20580236] |
| ChEMBL | Inhibition of eel AChE | B | 5.5 | pIC50 | 3180 | nM | IC50 | Bioorg Med Chem (2007) 15: 1034-1043 [PMID:17085051] |
| ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 5.51 | pIC50 | 3120 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 5.55 | pIC50 | 2800 | nM | IC50 | Eur J Med Chem (2017) 137: 280-291 [PMID:28605675] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 5.56 | pIC50 | 2770 | nM | IC50 | Medchemcomm (2014) 5: 609-616 |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as a substrate measured for 125 secs by DNTB reagent based Ellman's method | B | 5.57 | pIC50 | 2700 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1718-1725 [PMID:34795859] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition by Ellman's method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 2368-2373 [PMID:24726809] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180 seconds by Ellman's method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Eur J Med Chem (2013) 64: 540-553 [PMID:23685572] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2636-2641 [PMID:23511019] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Eur J Med Chem (2013) 69: 632-646 [PMID:24095756] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.62 | pIC50 | 2410 | nM | IC50 | Eur J Med Chem (2015) 102: 80-92 [PMID:26244990] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.62 | pIC50 | 2410 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
| ChEMBL | Inhibition of Electric eel AChE assessed as amount of thiocholine released using acetylthiocholine iodide as substrate after 6 mins by Ellman's method | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Nat Prod (2014) 77: 650-656 [PMID:24521095] |
| ChEMBL | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | B | 5.66 | pIC50 | 2200 | nM | IC50 | J Med Chem (2005) 48: 8270-8288 [PMID:16366609] |
| ChEMBL | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2014) 22: 906-916 [PMID:24369842] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2013) 21: 3022-3031 [PMID:23602518] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's microplate assay | B | 5.68 | pIC50 | 2090 | nM | IC50 | Eur J Med Chem (2013) 67: 221-229 [PMID:23871902] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins by spectrophotometer analysis | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1815-1819 [PMID:24594354] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2019) 27: 2621-2628 [PMID:30952387] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.69 | pIC50 | 2050 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2010) 73: 1632-1635 [PMID:20828184] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase | B | 5.74 | pIC50 | 1820 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2263-2266 [PMID:18356045] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by Ellman's method | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem (2018) 26: 4952-4962 [PMID:30190181] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay | B | 5.78 | pIC50 | 1670 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB reagent based Ellman's method | B | 5.78 | pIC50 | 1650 | nM | IC50 | Eur J Med Chem (2022) 242: 114630-114630 [PMID:35987018] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 5.84 | pIC50 | 1450 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2880-2882 [PMID:23583510] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.84 | pIC50 | 1450 | nM | IC50 | Eur J Med Chem (2018) 143: 1301-1311 [PMID:29126732] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as a substrate and measured for 125 sec by DTNB based Ellman's method | B | 5.89 | pIC50 | 1290 | nM | IC50 | Bioorg Med Chem (2022) 68: 116807-116807 [PMID:35653868] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.89 | pIC50 | 1280 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1325-1329 [PMID:30956012] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured every minute for fifteen minutes by Ellman's method | B | 5.99 | pIC50 | 1020 | nM | IC50 | Eur J Med Chem (2017) 127: 771-780 [PMID:27823880] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with compounds for 20 mins followed by substrate addition and measured after 20 mins by Ellman's method relative to control | B | 6 | pIC50 | 1000 | nM | IC50 | J Nat Prod (2023) 86: 939-946 [PMID:36808969] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 6.18 | pIC50 | 665 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
| ChEMBL | Inhibition of electric eel AChE by colorimetric Ellman's assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Eur J Med Chem (2011) 46: 3118-3123 [PMID:21546135] |
| ChEMBL | Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of electric eel AChE type 6S by Ellman's assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.19 | pIC50 | 640 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman's method | B | 6.2 | pIC50 | 636 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman's method | B | 6.2 | pIC50 | 635.33 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of electric eel AChE type 6S by Ellman's assay | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.2 | pIC50 | 635.33 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman method | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2010) 18: 1244-1251 [PMID:20056426] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848] |
| ChEMBL | Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4462-4466 [PMID:22633691] |
| ChEMBL | Inhibition of electric eel Acetylcholinesterase | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2011) 19: 2298-2305 [PMID:21397508] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's assay | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2010) 18: 4475-4484 [PMID:20471843] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2011) 19: 7228-7235 [PMID:22041172] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins followed by substrate addition by Ellman's method | B | 6.21 | pIC50 | 610 | nM | IC50 | Eur J Med Chem (2016) 122: 326-338 [PMID:27376495] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's method | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2885-2888 [PMID:22425563] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured upto 5 mins by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2019) 177: 414-424 [PMID:31158754] |
| ChEMBL | Inhibition of electric eel AChE pretreated for 20 mins followed by acetylthiocholine iodide substrate addition measured for 5 mins by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2017) 125: 288-298 [PMID:27688184] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | J Med Chem (2010) 53: 5129-5143 [PMID:20575555] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.26 | pIC50 | 550 | nM | IC50 | Eur J Med Chem (2009) 44: 2523-2532 [PMID:19243862] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.26 | pIC50 | 550 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3765-3768 [PMID:17451950] |
| ChEMBL | Inhibitory activity against AChE from electric eel | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) using acetylthiocholine iodide as substrate preincubated for 15 min | B | 6.3 | pIC50 | 500 | nM | IC50 | Med Chem Res (2012) 21: 2329-2339 |
| ChEMBL | Inhibition of electric eel AChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by DTNB-based spectrophotometric analysis | B | 6.32 | pIC50 | 480 | nM | IC50 | J Nat Prod (2016) 79: 1241-1248 [PMID:27096334] |
| ChEMBL | Compound was assessed for in vitro inhibition of Acetylcholinesterase isolated from Electrophorus electricus | B | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 637-639 [PMID:10762042] |
| ChEMBL | Inhibition of Electrophorus electricus AChE by Ellman's method | B | 6.44 | pIC50 | 360 | nM | IC50 | J Med Chem (2007) 50: 5311-5323 [PMID:17902635] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2017) 136: 294-304 [PMID:28505534] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pre-incubated for 5 mins followed by substrate addition and measured after 6 mins by Ellman's method | B | 6.82 | pIC50 | 150 | nM | IC50 | Eur J Med Chem (2022) 241: 114616-114616 [PMID:35870364] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB based Ellman's method | B | 6.88 | pIC50 | 132 | nM | IC50 | Eur J Med Chem (2023) 253: 115288-115288 [PMID:37031527] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Binding affinity to AChE (unknown origin) assessed as inhibition constant incubated for 30 mins by ellman's method | B | 6.27 | pKi | 540 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Binding affinity to AChE (unknown origin) assessed as inhibition constant | B | 6.3 | pKi | 500 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Inhibition of AChE by Ellman's assay | B | 6.52 | pKi | 300 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 5290-5294 [PMID:20655219] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's method | B | 6.6 | pKi | 250 | nM | Ki | Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine as substrate | B | 7.21 | pKi | 61.96 | nM | Ki | Bioorg Med Chem (2012) 20: 6739-6750 [PMID:23041347] |
| ChEMBL | Inhibition of human AChE assessed as acetylthiocholine hydrolysis | B | 7.21 | pKi | 61.9 | nM | Ki | Bioorg Med Chem (2014) 22: 4784-4791 [PMID:25088549] |
| ChEMBL | Inhibition of human acetylcholinesterase using ATCI/DTNB as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by Ellman method | B | 4.05 | pIC50 | 90000 | nM | IC50 | Bioorg Med Chem (2015) 23: 4567-4575 [PMID:26105711] |
| ChEMBL | Inhibition of AChE by spectrophotometry | B | 4.13 | pIC50 | 73900 | nM | IC50 | J Nat Prod (2009) 72: 500-502 [PMID:19215141] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by Ellman's method | B | 4.77 | pIC50 | 17100 | nM | IC50 | RSC Med Chem (2020) 11: 307-316 [PMID:33479638] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate pretreated for 15 mins followed by substrate addition and measured by DTNB reagent based assay | B | 4.86 | pIC50 | 13900 | nM | IC50 | J Nat Prod (2018) 81: 1693-1700 [PMID:30040425] |
| ChEMBL | Inhibition of human recombinant AChe using acetylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's method | B | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2022) 65: 12292-12318 [PMID:36084304] |
| ChEMBL | Inhibition of human erythrocytes BChE | B | 5.14 | pIC50 | 7300 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of human plasma BChE | B | 5.14 | pIC50 | 7300 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) | B | 5.19 | pIC50 | 6400 | nM | IC50 | Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080] |
| ChEMBL | Inhibition of human acetylcholinesterase | B | 5.42 | pIC50 | 3800 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate after 5 mins by DTNB method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4707-4712 [PMID:22704921] |
| ChEMBL | Inhibition of AChE by microplate assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Med Chem (2004) 47: 6248-6254 [PMID:15566295] |
| ChEMBL | Inhibition of AChE (unknown origin) using 2-nitrobenzoate-5-mercaptothiocholine as substrate after 15 to 60 mins by microplate assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2014) 22: 1262-1267 [PMID:24485122] |
| ChEMBL | Inhibition of AChE in human erythrocytes using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition measured for 15 mins by Ellman's method | B | 5.52 | pIC50 | 3030 | nM | IC50 | Eur J Med Chem (2019) 179: 404-422 [PMID:31265934] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine as substrate measured after 5 mins by Ellman's method | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2020) 191: 112140-112140 [PMID:32088494] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 25 mins by DTNB reagent based Ellman's method | B | 5.54 | pIC50 | 2900 | nM | IC50 | Bioorg Med Chem (2021) 42: 116269-116269 [PMID:34130217] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's spectrophotometric method | B | 5.56 | pIC50 | 2770 | nM | IC50 | Eur J Med Chem (2019) 178: 243-258 [PMID:31185414] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem (2014) 22: 3806-3814 [PMID:24934993] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method | B | 5.59 | pIC50 | 2600 | nM | IC50 | Medchemcomm (2015) 6: 1930-1941 |
| ChEMBL | Inhibition of human erythrocytes acetylcholinesterase after 15 mins | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Nat Prod (2011) 74: 86-89 [PMID:21189039] |
| ChEMBL | Inhibition of human recombinant AChE | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 745-751 [PMID:20025280] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2014) 22: 1318-1328 [PMID:24461561] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.68 | pIC50 | 2090 | nM | IC50 | Eur J Med Chem (2021) 211: 113102-113102 [PMID:33421712] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126789-126789 [PMID:31753696] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2979-2983 [PMID:23570788] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide substrate by Ellman's method based spectrophotometry | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2013) 21: 1696-1707 [PMID:23454132] |
| ChEMBL | Inhibition of human recombinant acetylcholinesterase | B | 5.7 | pIC50 | 2010 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
| ChEMBL | Inhibition of human recombinant AChE by Ellman's assay | B | 5.7 | pIC50 | 2010 | nM | IC50 | J Med Chem (2008) 51: 7308-7312 [PMID:18954037] |
| ChEMBL | Inhibition of human AChE | B | 5.7 | pIC50 | 2010 | nM | IC50 | J Med Chem (2013) 56: 7615-7624 [PMID:23984975] |
| ChEMBL | Inhibition of human acetylcholine esterase preincubated for 10 mins followed by the addition of 550 uM of acetylcholine iodide as substrate measured after 20 mins by Ellman's method | B | 5.7 | pIC50 | 2010 | nM | IC50 | Eur J Med Chem (2016) 108: 687-700 [PMID:26735910] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | B | 5.7 | pIC50 | 2010 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of AChE (unknown origin) by Ellman method | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2614-2618 [PMID:23540646] |
| ChEMBL | Inhibition of AChE (unknown origin) assessed as reduction in acetylthiocholine iodide hydrolysis after 15 mins by Ellman method | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 626-630 [PMID:25537270] |
| ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 1 min by Ellman's method | B | 5.7 | pIC50 | 2000 | nM | IC50 | Eur J Med Chem (2023) 252: 115301-115301 [PMID:36996715] |
| ChEMBL | Inhibition of human erythrocyte AChE using S-acetylthiocholine iodide as substrate pretreated for 20 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Nat Prod (2018) 81: 364-370 [PMID:29400966] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's method | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Nat Prod (2019) 82: 239-248 [PMID:30701972] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by spectrophotometry based Ellman's method | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1194-1198 [PMID:30910460] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) assessed as reduction in formation of 5-thio-2-nitrobenzoate from acetylthiocholine iodide preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 228-231 [PMID:27914796] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB reagent based Ellman's method | B | 5.89 | pIC50 | 1290 | nM | IC50 | Eur J Med Chem (2022) 242: 114630-114630 [PMID:35987018] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.9 | pIC50 | 1270 | nM | IC50 | J Nat Prod (2017) 80: 2462-2471 [PMID:28898076] |
| ChEMBL | Inhibition of AChE (unknown origin) using ATCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's method | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Nat Prod (2023) 86: 2162-2170 [PMID:37615114] |
| ChEMBL | Inhibition of human AChE by Ellman's assay | B | 5.93 | pIC50 | 1180 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| ChEMBL | Inhibition of AChE (unknown origin) incubated for 30 mins by Ellman's method | B | 5.93 | pIC50 | 1170 | nM | IC50 | Eur J Med Chem (2022) 233: 114242-114242 [PMID:35276424] |
| ChEMBL | DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) | B | 5.94 | pIC50 | 1156 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Inhibition of AChE (unknown origin) by Ellman colorimetric method | B | 5.96 | pIC50 | 1100 | nM | IC50 | Eur J Med Chem (2014) 78: 392-400 [PMID:24704612] |
| ChEMBL | Inhibition of AChE by Ellman method | B | 5.97 | pIC50 | 1070 | nM | IC50 | J Nat Prod (2007) 70: 1458-1461 [PMID:17822295] |
| ChEMBL | Inhibition of human AChE | B | 5.97 | pIC50 | 1070 | nM | IC50 | Eur J Med Chem (2017) 136: 294-304 [PMID:28505534] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6 | pIC50 | 1000 | nM | IC50 | Eur J Med Chem (2020) 208: 112792-112792 [PMID:32949964] |
| ChEMBL | Inhibition of human AChE pre-incubated for 10 mins before acetylthiocholine iodide substrate addition | B | 6 | pIC50 | 1000 | nM | IC50 | J Nat Prod (2012) 75: 1400-1404 [PMID:22775474] |
| ChEMBL | Inhibition of AChE by microplate assay | B | 6.01 | pIC50 | 980 | nM | IC50 | J Nat Prod (2000) 63: 803-806 [PMID:10869205] |
| ChEMBL | Inhibition of human plasma AChE | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of human erythrocytes AChE | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Ex vivo inhibition of human erythrocyte Acetylcholinesterase. | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
| ChEMBL | Anticholinesterase activity against human erythrocyte AChE | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human erythrocyte Acetylcholinesterase | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 6.1 | pIC50 | 790 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's method | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem (2014) 22: 5141-5154 [PMID:25189690] |
| ChEMBL | Inhibition of AChE | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of AChE | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition by Ellmans method | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem (2017) 25: 2057-2064 [PMID:28279561] |
| ChEMBL | Inhibition of AChE in human erythrocytes by Ellman's method | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2010) 53: 5129-5143 [PMID:20575555] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB based Ellman's method | B | 6.23 | pIC50 | 594 | nM | IC50 | Eur J Med Chem (2023) 253: 115288-115288 [PMID:37031527] |
| ChEMBL | Inhibition of AChE activity | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2170-2172 [PMID:16483771] |
| ChEMBL | Inhibition of human AChE by spectrophotometry | B | 6.26 | pIC50 | 550 | nM | IC50 | J Nat Prod (2014) 77: 894-901 [PMID:24606395] |
| ChEMBL | Inhibition of AChE by Ellman's method | B | 6.28 | pIC50 | 530 | nM | IC50 | J Nat Prod (2010) 73: 1858-1862 [PMID:20954721] |
| GtoPdb | - | - | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2565-8 [PMID:12182861] |
| ChEMBL | Inhibition of acetylcholinesterase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Nat Prod (2008) 71: 1481-1484 [PMID:18681480] |
| ChEMBL | Inhibition of AchE | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem (2008) 16: 7691-7697 [PMID:18650096] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 min prior to substrate addition measured for 15 min by spectrophotometric analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | Med Chem Res (2012) 21: 2772-2778 |
| ChEMBL | In vitro inhibition of human recombinant AChE. | B | 6.3 | pIC50 | ~500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2565-2568 [PMID:12182861] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.45 | pIC50 | 355 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
| ChEMBL | Inhibition of AChE-induced amyloid beta aggregation | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
| ChEMBL | Inhibition of human AChE | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 4848-4853 [PMID:26159481] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2021) 43: 116270-116270 [PMID:34153839] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem (2023) 84: 117256-117256 [PMID:37003157] |
| ChEMBL | Inhibition of human AChE by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2885-2888 [PMID:22425563] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
| ChEMBL | Inhibition AChE (unknown origin) using ATCI as substrate assessed as hydrolysis of ATCI after 10 mins measured every 1 min for 10 times | B | 6.52 | pIC50 | 300 | nM | IC50 | J Nat Prod (2016) 79: 281-292 [PMID:26841168] |
| ChEMBL | Inhibitory activity against acetylcholinesterase in human RBC | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 737-742 |
| ChEMBL | In vitro reversal of vecuronium-induced neuromuscular block in guinea pig hemi-diaphragm. | F | 5.96 | pEC50 | 1100 | nM | EC50 | Bioorg Med Chem Lett (2002) 12: 2565-2568 [PMID:12182861] |
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibition of bovine AChE by Elman's method | B | 5.06 | pIC50 | 8700 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] | ||||||||
| ChEMBL | Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate incubated 10 mins prior to substrate addition measured after 10 mins by Ellman's method | B | 5.6 | pIC50 | 2500 | nM | IC50 | Bioorg Med Chem (2014) 22: 1262-1267 [PMID:24485122] |
| ChEMBL | Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by modified Ellman's method | B | 5.68 | pIC50 | 2080 | nM | IC50 | Bioorg Med Chem (2015) 23: 231-240 [PMID:25468034] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
| ChEMBL | Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman method | B | 5.59 | pIC50 | 2550 | nM | IC50 | J Med Chem (2012) 55: 9708-9721 [PMID:23033965] |
| ChEMBL | Inhibitory activity against acetylcholinesterase in rat brain | B | 5.75 | pIC50 | 1760 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 737-742 |
| ChEMBL | Inhibition of AChE from rat cortex homogenate by Ellmans method | B | 5.93 | pIC50 | 1165 | nM | IC50 | Eur J Med Chem (2009) 44: 772-784 [PMID:18550228] |
| ChEMBL | Inhibition of rat brain acetylcholinesterase by colorimetric method | B | 6.04 | pIC50 | 920 | nM | IC50 | J Nat Prod (2004) 67: 1882-1885 [PMID:15568781] |
| ChEMBL | Inhibition against acetylcholinesterase (AChE) | B | 6.12 | pIC50 | 750 | nM | IC50 | J Med Chem (1994) 37: 689-695 [PMID:8126709] |
| ChEMBL | Acetylcholinesterase inhibitory activity in rat striatal homogenates | B | 6.2 | pIC50 | 630 | nM | IC50 | J Med Chem (1995) 38: 3645-3651 [PMID:7658452] |
| ChEMBL | In vitro inhibitory effect on rat Acetylcholinesterase | B | 6.27 | pIC50 | 538 | nM | IC50 | J Med Chem (1995) 38: 2969-2973 [PMID:7636858] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of BChE (unknown origin) pre-incubated for 15 mins before S-butyrylthiocholine chloride substrate addition and measured after 30 mins by colorimetric Ellman's method | B | 4.55 | pKi | 28290 | nM | Ki | Bioorg Med Chem (2016) 24: 4464-4469 [PMID:27492195] |
| ChEMBL | Binding affinity to BuChE (unknown origin) assessed as inhibition constant | B | 5.03 | pKi | 9400 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Binding affinity to BuChE (unknown origin) assessed as inhibition constant incubated for 30 mins by ellman's method | B | 5.03 | pKi | 9370 | nM | Ki | RSC Med Chem (2021) 12: 2001-2015 [PMID:35028560] |
| ChEMBL | Inhibition of human BChE assessed as acetylthiocholine hydrolysis | B | 6.72 | pKi | 192.5 | nM | Ki | Bioorg Med Chem (2014) 22: 4784-4791 [PMID:25088549] |
| ChEMBL | Inhibition of human recombinant BChE using acetylthiocholine as substrate | B | 6.72 | pKi | 192.47 | nM | Ki | Bioorg Med Chem (2012) 20: 6739-6750 [PMID:23041347] |
| ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method | B | 4.18 | pIC50 | 66500 | nM | IC50 | Medchemcomm (2015) 6: 1930-1941 |
| ChEMBL | Inhibition of BChE by spectrophotometry | B | 4.29 | pIC50 | 50900 | nM | IC50 | J Nat Prod (2009) 72: 500-502 [PMID:19215141] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's method | B | 4.37 | pIC50 | 42300 | nM | IC50 | J Nat Prod (2019) 82: 239-248 [PMID:30701972] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibition of recombinant human BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 1 min by Ellman's method | B | 4.47 | pIC50 | 34000 | nM | IC50 | Eur J Med Chem (2023) 252: 115301-115301 [PMID:36996715] |
| ChEMBL | Inhibition of human plasma BuChE using butyrylthiocholine as substrate measured after 5 mins by Ellman's method | B | 4.5 | pIC50 | 31600 | nM | IC50 | Eur J Med Chem (2020) 191: 112140-112140 [PMID:32088494] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine chloride as substrate by Ellman's method | B | 4.53 | pIC50 | 29310 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of human recombinant BuChE using butyrylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's method | B | 4.66 | pIC50 | 21900 | nM | IC50 | Bioorg Med Chem (2014) 22: 5141-5154 [PMID:25189690] |
| ChEMBL | Inhibition of human recombinant BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's spectrophotometric method | B | 4.68 | pIC50 | 20700 | nM | IC50 | Eur J Med Chem (2019) 178: 243-258 [PMID:31185414] |
| ChEMBL | Inhibition of human serum BChE by Ellman's assay | B | 4.68 | pIC50 | 20700 | nM | IC50 | J Med Chem (2008) 51: 7308-7312 [PMID:18954037] |
| ChEMBL | Inhibition of human recombinant butyrylcholinesterase | B | 4.68 | pIC50 | 20700 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
| ChEMBL | Inhibition of human recombinant BuChe using butyrylthiocholine iodide as substrate incubated for 10 mins by DTNB reagent based Ellman's method | B | 4.71 | pIC50 | 19710 | nM | IC50 | J Med Chem (2022) 65: 12292-12318 [PMID:36084304] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126789-126789 [PMID:31753696] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.72 | pIC50 | 19270 | nM | IC50 | Eur J Med Chem (2021) 211: 113102-113102 [PMID:33421712] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.72 | pIC50 | 19100 | nM | IC50 | Bioorg Med Chem (2023) 84: 117256-117256 [PMID:37003157] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.72 | pIC50 | 19100 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.73 | pIC50 | 18600 | nM | IC50 | Bioorg Med Chem (2021) 43: 116270-116270 [PMID:34153839] |
| ChEMBL | Inhibition of BChE | B | 4.73 | pIC50 | 18600 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
| ChEMBL | In vitro inhibitory activity against Butyrylcholinesterase (BChE) in human serum | B | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2389-2391 [PMID:12824041] |
| ChEMBL | Inhibition of BuChE in human serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition measured for 15 mins by Ellman's method | B | 4.78 | pIC50 | 16500 | nM | IC50 | Eur J Med Chem (2019) 179: 404-422 [PMID:31265934] |
| ChEMBL | Inhibition of BuChE in human serum using butyrylthiocholine iodide as substrate measured every 30s for 5 mins by Ellman's spectrophotometric method | B | 4.8 | pIC50 | 15800 | nM | IC50 | Eur J Med Chem (2014) 75: 21-30 [PMID:24508831] |
| ChEMBL | Inhibition of BChE (unknown origin) using BTCI as substrate preincubated for 15 min followed by substrate addition measured after 40 min by Ellman's method | B | 4.81 | pIC50 | 15600 | nM | IC50 | J Nat Prod (2023) 86: 2162-2170 [PMID:37615114] |
| ChEMBL | Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 4.86 | pIC50 | 13700 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by spectrophotometry based Ellman's method | B | 4.88 | pIC50 | 13180 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1194-1198 [PMID:30910460] |
| ChEMBL | Inhibition of BuChE (unknown origin) | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem (2014) 22: 3806-3814 [PMID:24934993] |
| ChEMBL | Inhibition of human serum BuChe using butyrylthiocholine iodide as substrate incubated for 25 mins by DTNB reagent based Ellman's method | B | 4.97 | pIC50 | 10600 | nM | IC50 | Bioorg Med Chem (2021) 42: 116269-116269 [PMID:34130217] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB reagent based Ellman's method | B | 5 | pIC50 | 10010 | nM | IC50 | Eur J Med Chem (2022) 242: 114630-114630 [PMID:35987018] |
| ChEMBL | Inhibition of BuChE (unknown origin) by spectrophotometric analysis based Ellman's assay | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 232-236 [PMID:27923619] |
| ChEMBL | Inhibition of human serum BuChE by Ellman's method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2007) 50: 5311-5323 [PMID:17902635] |
| ChEMBL | Inhibition of BuChE (unknown origin) by Ellman method | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2614-2618 [PMID:23540646] |
| ChEMBL | Inhibition of butyrylcholinesterase | B | 5.07 | pIC50 | 8500 | nM | IC50 | J Nat Prod (2008) 71: 1481-1484 [PMID:18681480] |
| ChEMBL | Inhibition of BChE | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 15 min | B | 5.1 | pIC50 | 8000 | nM | IC50 | Med Chem Res (2012) 21: 2329-2339 |
| ChEMBL | Inhibition of BchE | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7691-7697 [PMID:18650096] |
| ChEMBL | Ex vivo inhibition of human plasma Butyrylcholinesterase. | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
| ChEMBL | Anticholinesterase activity against human plasma BChE | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human plasma Butyrylcholinesterase | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 5.15 | pIC50 | 7000 | nM | IC50 | Eur J Med Chem (2018) 156: 598-617 [PMID:30031971] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) | B | 5.15 | pIC50 | 7000 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
| ChEMBL | Inhibition of BChE (unknown origin) using thiocholine as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.43 | pIC50 | 3720 | nM | IC50 | Eur J Med Chem (2018) 143: 1301-1311 [PMID:29126732] |
| ChEMBL | Inhibition of BChE (unknown origin) incubated for 30 mins by Ellman's method | B | 5.7 | pIC50 | 2015 | nM | IC50 | Eur J Med Chem (2022) 233: 114242-114242 [PMID:35276424] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate pretreated for 15 mins followed by substrate addition and measured by DTNB reagent based assay relative to control | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2018) 81: 1693-1700 [PMID:30040425] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition by Ellmans method | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem (2017) 25: 2057-2064 [PMID:28279561] |
| ChEMBL | Inhibition of human Cholinesterase | B | 6.24 | pIC50 | 575 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) using butyrylthiocholine chloride as substrate incubated for 15 min prior to substrate addition measured for 15 min by spectrophotometric analysis | B | 6.77 | pIC50 | 170 | nM | IC50 | Med Chem Res (2012) 21: 2772-2778 |
| Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9] | ||||||||
| ChEMBL | Inhibitory activity against BuChE from horse serum | B | 5.1 | pKi | 8000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2011) 19: 7228-7235 [PMID:22041172] |
| ChEMBL | Inhibition of equine serum Butyrylcholinesterase | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2011) 19: 2298-2305 [PMID:21397508] |
| ChEMBL | Inhibition of BuChE in horse serum | B | 4.82 | pIC50 | 15240 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2123-2125 [PMID:17317172] |
| ChEMBL | Inhibition of equine serum BuChE | B | 4.84 | pIC50 | 14400 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3765-3768 [PMID:17451950] |
| ChEMBL | Inhibitory activity against BuChE from horse serum | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's assay | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of horse serum BChE | B | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's assay | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of horse serum BChE | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
| ChEMBL | Inhibition of BChE from rat serum by Ellmans method | B | 5.23 | pIC50 | 5900 | nM | IC50 | Eur J Med Chem (2009) 44: 772-784 [PMID:18550228] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured for 125 secs by Ellman's method | B | 5.11 | pKi | 7700 | nM | Ki | Eur J Med Chem (2019) 181: 111550-111550 [PMID:31376562] |
| ChEMBL | Inhibition of horse serum butyrylcholinesterase by Ellman's method | B | 4.34 | pIC50 | 46030 | nM | IC50 | Eur J Med Chem (2016) 124: 270-283 [PMID:27592396] |
| ChEMBL | Inhibition of horse serum BChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 5 mins for 15 mins by spectrophotometric method | B | 4.39 | pIC50 | 40720 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2481-2484 [PMID:29887354] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4.41 | pIC50 | 39030 | nM | IC50 | Eur J Med Chem (2014) 76: 376-386 [PMID:24594525] |
| ChEMBL | Inhibition of equine BChE using S-butyrylthiocholine chloride as substrate by Ellman's method | B | 4.55 | pIC50 | 28300 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2308-2313 [PMID:26995529] |
| ChEMBL | Inhibition of equine BChE using BTC as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's assay | B | 4.55 | pIC50 | 28100 | nM | IC50 | Bioorg Med Chem (2016) 24: 886-893 [PMID:26795115] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.61 | pIC50 | 24410 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1325-1329 [PMID:30956012] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 4.61 | pIC50 | 24400 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| ChEMBL | Inhibition of equine serum BuChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by DTNB-based spectrophotometric analysis | B | 4.65 | pIC50 | 22390 | nM | IC50 | J Nat Prod (2016) 79: 1241-1248 [PMID:27096334] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 4.66 | pIC50 | 21850 | nM | IC50 | Eur J Med Chem (2017) 137: 280-291 [PMID:28605675] |
| ChEMBL | Inhibition of horse serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4.7 | pIC50 | 19780 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
| ChEMBL | Inhibition of equine serum butyrylcholinesterase using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2014) 22: 906-916 [PMID:24369842] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2019) 27: 2621-2628 [PMID:30952387] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2979-2983 [PMID:23570788] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2013) 21: 3022-3031 [PMID:23602518] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2014) 22: 1318-1328 [PMID:24461561] |
| ChEMBL | Inhibition of horse serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's microplate assay | B | 4.71 | pIC50 | 19340 | nM | IC50 | Eur J Med Chem (2013) 67: 221-229 [PMID:23871902] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins by spectrophotometer analysis | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1815-1819 [PMID:24594354] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride substrate by Ellman's method based spectrophotometry | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2013) 21: 1696-1707 [PMID:23454132] |
| ChEMBL | Inhibition of horse serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.74 | pIC50 | 18130 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.76 | pIC50 | 17380 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
| ChEMBL | Inhibition of horse serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.76 | pIC50 | 17380 | nM | IC50 | Eur J Med Chem (2015) 102: 80-92 [PMID:26244990] |
| ChEMBL | Inhibition of equine serum BuChE preincubated for 6 mins followed by addition of S-butyrylthiocholine iodide by Ellman's method | B | 4.79 | pIC50 | 16320 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3881-3885 [PMID:27426301] |
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB based Ellman's method | B | 4.79 | pIC50 | 16076 | nM | IC50 | Eur J Med Chem (2023) 253: 115288-115288 [PMID:37031527] |
| ChEMBL | Inhibition of equine serum BuChE preincubated for 5 mins followed by addition of butyrylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 4.8 | pIC50 | 15800 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
| ChEMBL | Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4462-4466 [PMID:22633691] |
| ChEMBL | Inhibition of horse serum BChE by Ellman's method | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2010) 18: 1244-1251 [PMID:20056426] |
| ChEMBL | Inhibition of equine serum BuChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2010) 18: 4475-4484 [PMID:20471843] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 4.84 | pIC50 | 14400 | nM | IC50 | Eur J Med Chem (2009) 44: 2523-2532 [PMID:19243862] |
| ChEMBL | Inhibition of horse BuChE using S-butyrylcholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 4.87 | pIC50 | 13610 | nM | IC50 | Medchemcomm (2014) 5: 609-616 |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 6 mins by spectrophotometric method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654] |
| ChEMBL | Inhibition of BuChE in equine serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition by Ellman's method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 2368-2373 [PMID:24726809] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2636-2641 [PMID:23511019] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180 seconds by Ellman's method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Eur J Med Chem (2013) 64: 540-553 [PMID:23685572] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylcholinesterase iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Eur J Med Chem (2013) 69: 632-646 [PMID:24095756] |
| ChEMBL | Inhibition of equine BuChE using butyrylthiocholine iodide as substrate after 5 mins by DTNB method | B | 4.9 | pIC50 | 12600 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4707-4712 [PMID:22704921] |
| ChEMBL | Inhibition of horse serum BChE using butyrylcholine chloride as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3368-3376 [PMID:28457693] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine as substrate preincubated for 20 mins followed by substrate addition and measured upto 5 mins by Ellman's method | B | 4.92 | pIC50 | 12000 | nM | IC50 | Eur J Med Chem (2019) 177: 414-424 [PMID:31158754] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2010) 53: 5129-5143 [PMID:20575555] |
| ChEMBL | Inhibition of horse serum BChE pretreated for 20 mins followed by butyrylthiocholine iodide substrate addition measured for 5 mins by Ellman's method | B | 4.92 | pIC50 | 11900 | nM | IC50 | Eur J Med Chem (2017) 125: 288-298 [PMID:27688184] |
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB reagent based Ellman's method | B | 4.93 | pIC50 | 11680 | nM | IC50 | Eur J Med Chem (2022) 242: 114630-114630 [PMID:35987018] |
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by Ellman's method | B | 5.03 | pIC50 | 9400 | nM | IC50 | Bioorg Med Chem (2018) 26: 4952-4962 [PMID:30190181] |
| ChEMBL | Inhibition of equine serum BChE by modified Ellman's method | B | 5.08 | pIC50 | 8404 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of equine serum BChE by colorimetric Ellman's assay | B | 5.08 | pIC50 | 8400 | nM | IC50 | Eur J Med Chem (2011) 46: 3118-3123 [PMID:21546135] |
| ChEMBL | Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assay | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of equine serum BChE by modified Ellman's method | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assay | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of equine serum BChE by colorimetric Ellman's assay | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Eur J Med Chem (2011) 46: 3118-3123 [PMID:21546135] |
| ChEMBL | Inhibition of equine BChE using after 10 mins by Ellman's method | B | 5.1 | pIC50 | 7960 | nM | IC50 | Bioorg Med Chem (2013) 21: 1735-1748 [PMID:23462716] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate pre-incubated for 5 mins followed by substrate addition and measured after 6 mins by Ellman's method | B | 5.1 | pIC50 | 7900 | nM | IC50 | Eur J Med Chem (2022) 241: 114616-114616 [PMID:35870364] |
| ChEMBL | Inhibition of Equine serum BuChE using S-butyrylthiocholine iodide as a substrate and measured for 125 sec by DTNB based Ellman's method | B | 5.26 | pIC50 | 5470 | nM | IC50 | Bioorg Med Chem (2022) 68: 116807-116807 [PMID:35653868] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as a substrate measured for 125 secs by DNTB reagent based Ellman's method | B | 5.41 | pIC50 | 3900 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1718-1725 [PMID:34795859] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay | B | 5.48 | pIC50 | 3310 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
| ChEMBL | Inhibition of horse serum BChE after 2 mins by Ellman's reaction | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Nat Prod (2010) 73: 1879-1883 [PMID:20964319] |
| GluN2B/Glutamate [NMDA] receptor subunit epsilon 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL311] [GtoPdb: 457] [UniProtKB: Q00960] | ||||||||
| ChEMBL | Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (2012) 55: 9708-9721 [PMID:23033965] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
