NE-100 [Ligand Id: 6679] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL190883 (NE-100) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4931] [UniProtKB: Q15125] | ||||||||
| ChEMBL | Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2005) 48: 4754-4764 [PMID:16033255] |
| 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5525] [UniProtKB: Q60490] | ||||||||
| ChEMBL | Displacement of [3H](+/-)-emopamil from delta8-delta7 sterol isomerase (SI) site in guinea pig liver membranes | B | 7.84 | pKi | 14.6 | nM | Ki | J Med Chem (2005) 48: 8237-8244 [PMID:16366605] |
| ChEMBL | Displacement of [3H](-)-(S)-emopamil from EBP in guinea pig liver membrane | B | 7.84 | pKi | 14.6 | nM | Ki | J Med Chem (2008) 51: 7523-7531 [PMID:19053780] |
| Sigma-1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4153] [UniProtKB: Q60492] | ||||||||
| ChEMBL | Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes | B | 8.99 | pKi | 1.03 | nM | Ki | J Med Chem (2005) 48: 8237-8244 [PMID:16366605] |
| ChEMBL | Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membrane without cerebellum | B | 8.99 | pKi | 1.03 | nM | Ki | J Med Chem (2008) 51: 7523-7531 [PMID:19053780] |
| σ2/Sigma intracellular receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105907] [GtoPdb: 2553] [UniProtKB: Q5BJF2] | ||||||||
| ChEMBL | Binding affinity to human sigma 2 receptor | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2022) 73: 117032-117032 [PMID:36202063] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Binding affinity to human sigma 1 receptor | B | 8.96 | pKi | 1.1 | nM | Ki | Bioorg Med Chem (2022) 73: 117032-117032 [PMID:36202063] |
| ChEMBL | Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand | B | 9 | pKi | 1 | nM | Ki | J Med Chem (2005) 48: 4754-4764 [PMID:16033255] |
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | Life Sci (1993) 53: PL285-90 [PMID:7901723] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
| ChEMBL | Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assay | F | 4.97 | pEC50 | 10700 | nM | EC50 | J Med Chem (2005) 48: 8237-8244 [PMID:16366605] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
