physostigmine [Ligand Id: 6598] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL94 (Cogmine, Eserin, Eserine, Eserinum, MCV-4484, NSC-30782, (-)-physostigmine, Physostigmine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californica | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate after 60 mins by Ellman's method | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2014) 22: 3341-3350 [PMID:24835788] |
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Tested for in vitro inhibition of acetylcholinesterase | B | 6 | pKi | 1000 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 1131-1132 |
| ChEMBL | Time dependent inhibition of Electric eel AChE assessed as stability constants of inhibitor-enzyme complex using acetylthiocholine as substrate after 60 mins | B | 7.47 | pKi | 34 | nM | Ki | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in electric eel | B | 4.28 | pIC50 | 53000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of electric eel AChE | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Nat Prod (1996) 59: 890-893 |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 15 mins by Ellman's method relative to control | B | 5.93 | pIC50 | 1170 | nM | IC50 | RSC Med Chem (2020) 11: 518-527 [PMID:33479653] |
| ChEMBL | Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay | B | 6.56 | pIC50 | 275 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 861-864 |
| ChEMBL | Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate measured after 30 mins by Ellman's microplate assay | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2016) 24: 4464-4469 [PMID:27492195] |
| ChEMBL | Inhibition of electric eel AchE by Ellman's method | B | 6.99 | pIC50 | 103 | nM | IC50 | J Med Chem (2008) 51: 6400-6409 [PMID:18817366] |
| ChEMBL | Inhibition of electric eel AChE using ATC iodide substrate by DTNB based assay | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2014) 22: 5020-5034 [PMID:25059502] |
| ChEMBL | Inhibition of Electric eel AChE using acetylthiocholine as substrate after 2 mins | B | 7.05 | pIC50 | 90 | nM | IC50 | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | In vitro inhibitory activity against acetylcholinesterase from electric eel | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (1988) 31: 2297-2300 [PMID:3193422] |
| ChEMBL | Inhibition of electric eel AChE type 6S | B | 7.28 | pIC50 | 53 | nM | IC50 | J Med Chem (2010) 53: 1190-1199 [PMID:20067290] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in electric eel | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman method | B | 7.39 | pIC50 | 41 | nM | IC50 | J Nat Prod (2003) 66: 739-742 [PMID:12828454] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 7.39 | pIC50 | 41 | nM | IC50 | J Nat Prod (2001) 64: 842-844 [PMID:11421762] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Eur J Med Chem (2017) 138: 396-406 [PMID:28688279] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in electric eel | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of electric eel AChE incubated for 15 mins by Ellman's method | B | 8.11 | pIC50 | 7.8 | nM | IC50 | J Nat Prod (2019) 82: 2627-2637 [PMID:31433188] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 8.11 | pIC50 | 7.7 | nM | IC50 | Eur J Med Chem (2014) 81: 15-21 [PMID:24819955] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by Ellman's method | B | 8.52 | pIC50 | 3 | nM | IC50 | J Nat Prod (2019) 82: 2489-2500 [PMID:31429569] |
| ChEMBL | Inhibitory activity against acetylcholinesterase as a prodrug was demonstarted | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 123-126 |
| Acetylcholinesterase in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227914] [UniProtKB: P36196] | ||||||||
| ChEMBL | Inhibition of acetylcholine esterase in chicken biventer cervicis muscle assessed as rate of acetylcholine hydrolysis by Ellman's method | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1979) 22: 117-119 [PMID:423175] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human AChE by Ellmans test | B | 1.45 | pIC50 | 1.45 | - | logIC50 | J Med Chem (2010) 53: 6490-6505 [PMID:20684567] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in erythrocyte | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in cortex | B | 4.66 | pIC50 | 22000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of recombinant human AChE | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2005) 48: 4444-4456 [PMID:15974596] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.47 | pIC50 | 3390 | nM | IC50 | Eur J Med Chem (2021) 221: 113492-113492 [PMID:33984802] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 2 mins by Ellman's method | B | 6.27 | pIC50 | 538 | nM | IC50 | J Nat Prod (2020) 83: 1424-1431 [PMID:32239935] |
| ChEMBL | Inhibition of AChE | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of AChE | B | 6.31 | pIC50 | 493.17 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
| ChEMBL | Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 1 min by Ellman's method | B | 6.7 | pIC50 | 200 | nM | IC50 | Eur J Med Chem (2023) 252: 115301-115301 [PMID:36996715] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's method | B | 6.72 | pIC50 | 190 | nM | IC50 | RSC Med Chem (2022) 13: 1644-1656 [PMID:36561075] |
| ChEMBL | DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) | B | 6.76 | pIC50 | 175 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition measured after 10 mins by Ellman's method | B | 6.8 | pIC50 | 160 | nM | IC50 | Medchemcomm (2012) 3: 213-218 |
| ChEMBL | Inhibition of human erythrocyte AChE assessed as acetylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem (2012) 20: 2595-2602 [PMID:22445674] |
| ChEMBL | In vitro inhibitory activity against human acetylcholinesterase | F | 6.89 | pIC50 | 128 | nM | IC50 | J Med Chem (1994) 37: 1996-2000 [PMID:8027982] |
| ChEMBL | Concentration required to inhibit acetylcholinesterase isolated from human erythrocytes | B | 6.89 | pIC50 | 128 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 47-50 |
| ChEMBL | In vitro inhibitory activity against human AchE (Acetylcholinesterase) | B | 6.89 | pIC50 | 128 | nM | IC50 | J Med Chem (1992) 35: 1429-1434 [PMID:1573636] |
| ChEMBL | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate measured after 30 mins by Ellman's method | B | 7.1 | pIC50 | 80 | nM | IC50 | Eur J Med Chem (2020) 206: 112718-112718 [PMID:32861919] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 30 mins by Ellman's microplate assay | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3785-3792 [PMID:27236720] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 7.2 | pIC50 | 63 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay | B | 7.21 | pIC50 | 61 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 861-864 |
| ChEMBL | Inhibition acetylcholinesterase (AChE) enzyme. | B | 7.24 | pIC50 | 57.02 | nM | IC50 | J Med Chem (1997) 40: 4360-4371 [PMID:9435905] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase | B | 7.24 | pIC50 | 57 | nM | IC50 | J Med Chem (1996) 39: 5064-5071 [PMID:8978837] |
| ChEMBL | Inhibition of human AChE by Ellmans test | B | 7.25 | pIC50 | 56.7 | nM | IC50 | J Med Chem (2010) 53: 6490-6505 [PMID:20684567] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in human erythrocytes | B | 7.33 | pIC50 | 47 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | The compound was evaluated for the inhibition of human Acetylcholinesterase | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1992) 35: 1102-1108 [PMID:1552502] |
| ChEMBL | In vitro inhibition of human acetylcholinesterase. | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1992) 35: 3141-3147 [PMID:1507203] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 30 mins before substrate addition measured after 30 mins by Ellman method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2015) 23: 6014-6024 [PMID:26189031] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetyl thiocholine iodide as substrate after 30 mins by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Med Chem Res (2013) null: 1-12 |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in erythrocyte | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of human acetylcholinesterase using acetylcholine iodide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 mins by Ellman's spectrophotometric method | B | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (2016) 59: 2067-2082 [PMID:26886849] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in cortex | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of Acetylcholinesterase (AChE) from human RBC | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 2077-2080 |
| ChEMBL | Inhibitory concentration against acetylcholinesterase | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2711-2715 [PMID:15878275] |
| ChEMBL | Inhibitory concentration against human erythrocyte Acetylcholinesterase | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | In vitro inhibition of human erythrocyte acetylcholinesterase. | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2001) 44: 4062-4071 [PMID:11708910] |
| ChEMBL | Anticholinesterase activity against human erythrocyte AChE | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 7.55 | pIC50 | 28 | nM | IC50 | Eur J Med Chem (2022) 240: 114606-114606 [PMID:35858523] |
| ChEMBL | Anticholinesterase activity against erythrocyte acetylcholinesterase (AChE) in humans. | B | 7.55 | pIC50 | 27.9 | nM | IC50 | J Med Chem (1998) 41: 2371-2379 [PMID:9632370] |
| ChEMBL | Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique | B | 7.55 | pIC50 | 27.9 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-4693 [PMID:20627738] |
| ChEMBL | Inhibition of human acetylcholinesterase from erythrocytes (RBC) | B | 7.55 | pIC50 | 27.9 | nM | IC50 | J Med Chem (1997) 40: 2895-2901 [PMID:9288171] |
| ChEMBL | Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytes | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (1994) 37: 2721-2734 [PMID:8064800] |
| ChEMBL | In vitro inhibition of Acetylcholinesterase from human erythrocytes | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (1995) 38: 2802-2808 [PMID:7636841] |
| ChEMBL | Inhibition against Acetylcholinesterase (AChE) | B | 7.72 | pIC50 | 18.97 | nM | IC50 | J Med Chem (1996) 39: 380-387 [PMID:8558505] |
| ChEMBL | Concentration required to inhibit 50% of Acetylcholinesterase obtained from human erythrocytes was determined in vitro | B | 7.72 | pIC50 | 18.9 | nM | IC50 | J Med Chem (1995) 38: 1084-1089 [PMID:7707311] |
| ChEMBL | Inhibitory activity against acetylcholinesterase in human erythrocytes | B | 7.75 | pIC50 | 17.78 | nM | IC50 | J Med Chem (2001) 44: 105-109 [PMID:11141093] |
| ChEMBL | Inhibitory concentration against acetylcholinesterase from human erythrocytes | B | 7.75 | pIC50 | 17.78 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2022) 229: 114044-114044 [PMID:34923430] |
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
| ChEMBL | Inhibition of acetylcholinesterase (AChE) of human erythrocytes | B | 7.85 | pIC50 | 14.13 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | In vitro inhibition of human erythrocyte Acetylcholinesterase. | B | 7.85 | pIC50 | 14.1 | nM | IC50 | J Med Chem (2001) 44: 3810-3820 [PMID:11689067] |
| ChEMBL | Inhibition of human recombinant AChE | B | 7.87 | pIC50 | 13.49 | nM | IC50 | J Med Chem (2004) 47: 6490-6498 [PMID:15588084] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by spectrophotometric analysis | B | 8.54 | pIC50 | 2.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4248-4252 [PMID:23746477] |
| ChEMBL | In vitro inhibitory activity against acetylcholinesterase | B | 9.37 | pIC50 | 0.43 | nM | IC50 | J Med Chem (1992) 35: 584-589 [PMID:1738151] |
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibition of bovine AChE by Elman's method | B | 5.59 | pIC50 | 2580 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in bovine brain | B | 6.84 | pIC50 | 146 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in bovine erythrocytes | B | 6.91 | pIC50 | 123 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Concentration required to inhibit hydrolytic activity of Acetylcholinesterase by 50% | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (1991) 34: 1582-1584 [PMID:2033583] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] | ||||||||
| ChEMBL | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1718-1720 [PMID:20137934] |
| ChEMBL | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1721-1723 [PMID:20137941] |
| ChEMBL | In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate. | B | 9.16 | pIC50 | 0.69 | nM | IC50 | J Med Chem (1992) 35: 4542-4548 [PMID:1469686] |
| ChEMBL | Inhibitory activity against acetylcholinesterase | B | 9.17 | pIC50 | 0.68 | nM | IC50 | J Med Chem (1995) 38: 4821-4829 [PMID:7490731] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
| ChEMBL | Inhibitory activity against acetylcholine esterase (AChE) | B | 6.72 | pIC50 | 190 | nM | IC50 | J Med Chem (1994) 37: 689-695 [PMID:8126709] |
| ChEMBL | In vitro inhibitory effect on rat Acetylcholinesterase | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (1995) 38: 2969-2973 [PMID:7636858] |
| ChEMBL | Inhibition of rat acetylcholinesterase (AChE) | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (1998) 41: 3976-3986 [PMID:9767635] |
| ChEMBL | Inhibition of AChE in Wistar rat brain homogenate using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2012) 20: 4901-4914 [PMID:22831800] |
| ChEMBL | Inhibitory concentration against rat brain acetylcholinesterase AChE | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1998) 41: 3976-3986 [PMID:9767635] |
| ChEMBL | Inhibition of rat brain AChE by Ellman's method | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1532-1534 [PMID:20144867] |
| ChEMBL | Inhibitory concentration in vitro and ex vivo for anti-AChE activity in rat brain | B | 9.17 | pIC50 | 0.68 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 871-876 |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase | B | 5.3 | pKi | 5000 | nM | Ki | J Med Chem (1989) 32: 1522-1528 [PMID:2738887] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in cortex | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of isolated human BuChE | B | 4.64 | pIC50 | 23000 | nM | IC50 | J Med Chem (2005) 48: 4444-4456 [PMID:15974596] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in plasma | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of BChE | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE | B | 5.93 | pIC50 | 1164.13 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellman's method | B | 6.03 | pIC50 | 930 | nM | IC50 | Eur J Med Chem (2014) 80: 228-242 [PMID:24780600] |
| ChEMBL | Inhibition of BChE | B | 6.07 | pIC50 | 857 | nM | IC50 | J Nat Prod (2003) 66: 739-742 [PMID:12828454] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 30 mins before substrate addition measured after 30 mins by Ellman method | B | 6.07 | pIC50 | 850 | nM | IC50 | Bioorg Med Chem (2015) 23: 6014-6024 [PMID:26189031] |
| ChEMBL | Inhibition of BuChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 6.07 | pIC50 | 850 | nM | IC50 | Eur J Med Chem (2019) 180: 656-672 [PMID:31352246] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyryl thiocholine iodide as substrate after 30 mins by Ellman's method | B | 6.07 | pIC50 | 850 | nM | IC50 | Med Chem Res (2013) null: 1-12 |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine chloride as substrate by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of recombinant human BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 1 min by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2023) 252: 115301-115301 [PMID:36996715] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 6.89 | pIC50 | 130 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in cortex | B | 6.89 | pIC50 | 129 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | In vitro inhibition of Butyrylcholinesterase from human serum | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1995) 38: 2802-2808 [PMID:7636841] |
| ChEMBL | Concentration required to inhibit 50% of Butyrylcholinesterase obtained from human serum was determined in vitro | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1995) 38: 1084-1089 [PMID:7707311] |
| ChEMBL | The compound was evaluated for the inhibition human of Butyrylcholinesterase | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1992) 35: 1102-1108 [PMID:1552502] |
| ChEMBL | In vitro inhibition of human butryl cholinesterase. | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1992) 35: 3141-3147 [PMID:1507203] |
| ChEMBL | Inhibition of human plasma BuchE by Ellman's method | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2008) 51: 6400-6409 [PMID:18817366] |
| ChEMBL | Inhibition of human recombinant BChE | B | 7.58 | pIC50 | 26.3 | nM | IC50 | J Med Chem (2004) 47: 6490-6498 [PMID:15588084] |
| ChEMBL | In vitro inhibition of human serum Butyrylcholinesterase. | B | 7.64 | pIC50 | 23.1 | nM | IC50 | J Med Chem (2001) 44: 3810-3820 [PMID:11689067] |
| ChEMBL | Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)] | B | 7.64 | pIC50 | 22.91 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Inhibitory concentration against butyrylcholinesterase from human serum | B | 7.64 | pIC50 | 22.91 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
| ChEMBL | Inhibition of BuChE in human liver microsomes | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2010) 53: 1190-1199 [PMID:20067290] |
| ChEMBL | Anticholinesterase activity against human plasma BChE | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human plasma Butyrylcholinesterase | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of human Butyrylcholinesterase | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1997) 40: 2895-2901 [PMID:9288171] |
| ChEMBL | In vitro inhibition of human plasma butyrylcholinesterase. | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2001) 44: 4062-4071 [PMID:11708910] |
| ChEMBL | Anticholinesterase activity against plasma Butyrylcholinesterase (BChE) in humans. | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1998) 41: 2371-2379 [PMID:9632370] |
| ChEMBL | Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-4693 [PMID:20627738] |
| ChEMBL | Inhibition of BuChE (unknown origin) | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2022) 229: 114044-114044 [PMID:34923430] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2022) 240: 114606-114606 [PMID:35858523] |
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in plasma | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9] | ||||||||
| ChEMBL | Inhibition of (BChE) Butyrylcholinesterase of horse serum | B | 5.33 | pIC50 | 4666.7 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 861-864 |
| ChEMBL | Inhibition of equine BChE assessed as butyrylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry | B | 5.43 | pIC50 | 3700 | nM | IC50 | Bioorg Med Chem (2012) 20: 2595-2602 [PMID:22445674] |
| ChEMBL | Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serum | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1994) 37: 2721-2734 [PMID:8064800] |
| ChEMBL | Compound was evaluated for its inhibitory concentration against Horse serum Butyrylcholinesterase | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2747-2750 [PMID:9873615] |
| butyrylcholinesterase/Butyrylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311] | ||||||||
| ChEMBL | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | B | 6.55 | pIC50 | 280 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1718-1720 [PMID:20137934] |
| ChEMBL | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | B | 6.55 | pIC50 | 280 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1721-1723 [PMID:20137941] |
| Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
| ChEMBL | Inhibition of BuChE in Wistar rat plasma using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method | B | 7.23 | pIC50 | 58.4 | nM | IC50 | Bioorg Med Chem (2012) 20: 4901-4914 [PMID:22831800] |
| ChEMBL | Inhibition of isolated Butyrylcholinesterase (BuChE ) | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1998) 41: 3976-3986 [PMID:9767635] |
| ChEMBL | Butyrylcholinesterase | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (1995) 38: 4821-4829 [PMID:7490731] |
| ChEMBL | In vitro inhibitory concentration against butyrylcholinesterase (BuChE) obtained from rat plasma | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (1992) 35: 4542-4548 [PMID:1469686] |
| ChEMBL | Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasma | B | 8.09 | pIC50 | 8.1 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 871-876 |
| ChEMBL | Inhibition of rat plasma BChE by Ellman's method | B | 8.12 | pIC50 | 7.6 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1532-1534 [PMID:20144867] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Time dependent inhibition of equine serum BChE assessed as stability constants of inhibitor-enzyme complex using acetylthiocholine as substrate after 60 mins | B | 7.39 | pKi | 41 | nM | Ki | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| ChEMBL | Inhibition of horse BChE | B | 6.07 | pIC50 | 857 | nM | IC50 | J Nat Prod (2001) 64: 842-844 [PMID:11421762] |
| ChEMBL | Inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 6.07 | pIC50 | 850 | nM | IC50 | Eur J Med Chem (2017) 138: 396-406 [PMID:28688279] |
| ChEMBL | Inhibition of equine serum BChE preincubated for 15 mins followed by addition of S-butyrylthiocholine chloride as substrate measured after 30 mins by Ellman's microplate assay | B | 6.24 | pIC50 | 580 | nM | IC50 | Bioorg Med Chem (2016) 24: 4464-4469 [PMID:27492195] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 30 mins by Ellman's microplate assay | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3785-3792 [PMID:27236720] |
| ChEMBL | Inhibition of equine serum butyrylcholinesterase using butyrylcholine iodide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 mins by Ellman's spectrophotometric method | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (2016) 59: 2067-2082 [PMID:26886849] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 7.22 | pIC50 | 60 | nM | IC50 | Eur J Med Chem (2014) 81: 15-21 [PMID:24819955] |
| ChEMBL | Inhibition of equine serum BChE using acetylthiocholine as substrate after 2 mins | B | 7.38 | pIC50 | 42 | nM | IC50 | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | Inhibition of equine serum BChE using ATC iodide substrate by DTNB based assay | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2014) 22: 5020-5034 [PMID:25059502] |
| ChEMBL | Inhibition of BChE in horse serum using butyrylthiocholine iodide as substrate after 120 mins by Ellman's method | B | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem (2014) 22: 3341-3350 [PMID:24835788] |
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 6.7 | pIC50 | 200 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657] | ||||||||
| ChEMBL | Binding affinity against mouse muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]pirenzepine | B | 4.43 | pIC50 | 37000 | nM | IC50 | J Med Chem (1992) 35: 3141-3147 [PMID:1507203] |
| ChEMBL | Compound was evaluated for the competitive inhibition of [3H]pirenzepine binding to muscarinic acetylcholine receptor M1 of mouse cerebral cortex | B | 4.43 | pIC50 | 37000 | nM | IC50 | J Med Chem (1992) 35: 1102-1108 [PMID:1552502] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
