eptifibatide [Ligand Id: 6585] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1174 (Eptifibatida, Eptifibatide, Eptifibatide accord, Integrelin, Integrilin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] | ||||||||
| ChEMBL | Inhibition of fibrinogen binding to alpha IIb beta-3 integrin using thrombin inhibitor PPACK as anticoagulant | F | 6.24 | pIC50 | 570 | nM | IC50 | J Med Chem (2000) 43: 3453-3473 [PMID:10999999] |
| ChEMBL | Inhibition of human platelet aggregation collected with sodium citrate as anticoagulant | F | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2000) 43: 3453-3473 [PMID:10999999] |
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756] | ||||||||
| ChEMBL | Inhibition of human integrin alphavbeta3 (unknown origin) | B | 6.92 | pKd | 120 | nM | Kd | J Med Chem (2020) 63: 5675-5696 [PMID:31999923] |
| integrin αIIbβ3 in Human [GtoPdb: 2579] | ||||||||
| GtoPdb | inhibition of human platelet aggregation. The IC50 varies according to the anti-coagulant used during blood collection. | - | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2000) 43: 3453-73 [PMID:10999999] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
