Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL579 (SCH 33861, SCH-33861, Spiraprilat, Spirapril diacid) |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
ChEMBL | Compound tested in vitro for inhibition of Angiotensin I converting enzyme | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
GtoPdb | - | - | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (1989) 32: 1600-6 [PMID:2544729] |
Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
ChEMBL | In vitro inhibitory activity against angiotensin I converting enzyme of rats. | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
ChEMBL | Compound tested in vivo for inhibition of Angiotensin I converting enzyme in rat | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]