S 17092 [Ligand Id: 6565] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1086968 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] | ||||||||
| GtoPdb | - | - | 8.8 | pKi | 1.5 | nM | Ki | J Med Chem (2010) 53: 3423-38 [PMID:20058865] |
| ChEMBL | Inhibition of human POP | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2010) 53: 3423-3438 [PMID:20058865] |
| ChEMBL | Inhibition of human POP using Z-Gly-Pro-7-AMC substrate | B | 8.82 | pKi | 1.5 | nM | Ki | J Med Chem (2016) 59: 4221-4234 [PMID:26619267] |
| ChEMBL | Inhibition of human recombinant POP expressed in sEscherichia coli | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4360-4363 [PMID:18606544] |
| prolyl endopeptidase/Prolyl endopeptidase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4035] [GtoPdb: 2395] [UniProtKB: O70196] | ||||||||
| ChEMBL | inhibition of rat cortex POP | B | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2010) 53: 3423-3438 [PMID:20058865] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
