NS 2028 [Ligand Id: 6554] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL507122 (NS-2028) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Guanylyl cyclase-A/Atrial natriuretic peptide receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1988] [GtoPdb: 1747] [UniProtKB: P16066] | ||||||||
| ChEMBL | Inhibition of guanylate cyclase | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (2008) 51: 4150-4169 [PMID:18588282] |
| PvdQ in Pseudomonas aeruginosa (strain LESB58) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741161] [UniProtKB: Q9I194] | ||||||||
| ChEMBL | Inhibition of Pseudomonas aeruginosa ATCC 15692 pvdQ | B | 4.19 | pIC50 | 65000 | nM | IC50 | J Med Chem (2016) 59: 5929-5969 [PMID:26804741] |
| ChEMBL | Inhibition of Pseudomonas aeruginosa ATCC 15692 pvdQ incubated for 4 hrs | B | 7.7 | pIC50 | <20 | nM | IC50 | J Med Chem (2016) 59: 5929-5969 [PMID:26804741] |
| Guanylyl cyclase, α1β1 in Bovine [GtoPdb: 1287] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | - | - | - | Br J Pharmacol (1998) 123: 299-309 [PMID:9489619] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
