ChEMBL ligand: CHEMBL252937
Anionic trypsin-1 in Rat [ChEMBL: CHEMBL3638328] [UniProtKB: P00762] There should be some charts here, you may need to enable JavaScript!
plasminogen/Plasminogen in Rat [ChEMBL: CHEMBL3204] [GtoPdb: 2394] [UniProtKB: Q01177] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Rat [ChEMBL: CHEMBL3078] [GtoPdb: 2362] [UniProtKB: P18292] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235] There should be some charts here, you may need to enable JavaScript!
Urokinase plasminogen activator surface receptor in Rat [ChEMBL: CHEMBL3638329] [UniProtKB: P49616] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Anionic trypsin-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3638328] [UniProtKB: P00762]
ChEMBL	Enzyme Assay: Inhibition constant of the compound against Trypsin	B	7.66	pKi	22	nM	Ki	US-8476306-B2. Urokinase inhibitors, production and use thereof (2013)
plasminogen/Plasminogen in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3204] [GtoPdb: 2394] [UniProtKB: Q01177]
ChEMBL	Enzyme Assay: Inhibition constant of the compound against Plasmin	B	6.12	pKi	750	nM	Ki	US-8476306-B2. Urokinase inhibitors, production and use thereof (2013)
coagulation factor II, thrombin/Thrombin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3078] [GtoPdb: 2362] [UniProtKB: P18292]
ChEMBL	Enzyme Assay: Inhibition constant of the compound against Thrombin	B	4.85	pKi	14000	nM	Ki	US-8476306-B2. Urokinase inhibitors, production and use thereof (2013)
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235]
ChEMBL	Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader analysis	B	7.11	pKi	78	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
Urokinase plasminogen activator surface receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3638329] [UniProtKB: P49616]
ChEMBL	Enzyme Assay: Inhibition constant of the compound against Plasminogen activator urokinase	B	7.6	pKi	25	nM	Ki	US-8476306-B2. Urokinase inhibitors, production and use thereof (2013)
plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749]
ChEMBL	Inhibition of human uPA	B	7.7	pKi	20	nM	Ki	J Med Chem (2015) 58: 9238-9257 [PMID:26575094]
ChEMBL	Inhibition of uPA	B	7.7	pIC50	20	nM	IC50	J Med Chem (2008) 51: 183-186 [PMID:18163548]
GtoPdb	-	-	7.7	pIC50	20	nM	IC50	J Med Chem (2008) 51: 183-6 [PMID:18163548]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]