ChEMBL ligand: CHEMBL54044 (FTI-276)
farnesyltransferase, CAAX box, subunit alpha/Geranylgeranyl transferase type I in Human [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354, P53609] There should be some charts here, you may need to enable JavaScript!
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356] Protein farnesyltransferase in Bovine [ChEMBL: CHEMBL2095178] [UniProtKB: P29702, P49355] farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Mouse [ChEMBL: CHEMBL2096912] [GtoPdb: 2825, 2826] [UniProtKB: Q61239, Q8K2I1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyltransferase, CAAX box, subunit alpha/Geranylgeranyl transferase type I in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095164] [GtoPdb: 2825] [UniProtKB: P49354, P53609]
ChEMBL	Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranyl	B	7.3	pIC50	50	nM	IC50	Medchemcomm (2013) 4: 476-492 [PMID:25530833]
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094108] [GtoPdb: 2825, 2826] [UniProtKB: P49354, P49356]
ChEMBL	Inhibition of human FTase after 15 mins by fluorimetric analysis	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1261-1264 [PMID:21256013]
ChEMBL	Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence assay	B	8.15	pIC50	7	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3730-3734 [PMID:27282741]
ChEMBL	Inhibition of Trypanosoma brucei protein farnesyltransferase	B	8.77	pIC50	1.7	nM	IC50	J Med Chem (2004) 47: 432-445 [PMID:14711313]
ChEMBL	Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells	B	9.21	pIC50	0.61	nM	IC50	J Med Chem (2002) 45: 177-188 [PMID:11754590]
ChEMBL	Inhibitory concentration against farnesyltransferase was determined	B	9.22	pIC50	0.6	nM	IC50	J Med Chem (2004) 47: 1869-1878 [PMID:15055985]
ChEMBL	Inhibitory activity against farnesyltransferase (FT) using SPA assay	B	9.29	pIC50	0.51	nM	IC50	Bioorg Med Chem Lett (1999) 9: 703-708 [PMID:10201832]
GtoPdb	-	-	9.3	pIC50	0.5	nM	IC50	J Biol Chem (1995) 270: 26802-6 [PMID:7592920]
ChEMBL	Inhibition of mammalian Farnesyltransferase	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (2001) 11: 761-764 [PMID:11277514]
ChEMBL	Inhibition of mammalian protein farnesyltransferase	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2004) 47: 432-445 [PMID:14711313]
ChEMBL	In vitro inhibitory activity was evaluated against farnesyltransferase (FTase)	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1069-1074 [PMID:10328287]
ChEMBL	Inhibition of human recombinant FTase using [3H]farnesyldiphosphate	B	9.3	pIC50	0.5	nM	IC50	Medchemcomm (2013) 4: 476-492 [PMID:25530833]
ChEMBL	Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLS	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2018) 61: 3239-3252 [PMID:28505447]
ChEMBL	Inhibition of [3H]FPP incorporation into Ha-ras protein by Farnesyltransferase	F	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2963-2965 [PMID:11677136]
Protein farnesyltransferase in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095178] [UniProtKB: P29702, P49355]
ChEMBL	In vitro inhibition of farnesyltransferase from bovine brain	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (1998) 41: 4288-4300 [PMID:9784104]
farnesyltransferase, CAAX box, subunit alpha/farnesyltransferase, CAAX box, subunit beta/Protein farnesyltransferase in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096912] [GtoPdb: 2825, 2826] [UniProtKB: Q61239, Q8K2I1]
ChEMBL	Inhibition of mammalian H-Ras processing in NIH 3T3 cells	F	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2001) 11: 761-764 [PMID:11277514]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]