ChEMBL ligand: CHEMBL2151790
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
ChEMBL	Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counter	B	4	pKi	>100000	nM	Ki	Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332]
GtoPdb	-	-	7.48	pEC50	33	nM	EC50	ACS Chem Neurosci (2010) 1: 702-716 [PMID:20981342]
ChEMBL	Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization	F	7.48	pEC50	33	nM	EC50	Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332]
ChEMBL	Positive allosteric modulation of rat mGluR5	B	7.48	pEC50	33	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]