lisinopril [Ligand Id: 6360] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1237 (Lisinopril anhydrous) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibition of recombinant ACE N domain | B | 6.88 | pKi | 131.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850] |
| ChEMBL | Inhibition of somatic ACE N domain | B | 6.88 | pKi | 131.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843] |
| ChEMBL | Inhibition of testis ACE C domain | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843] |
| ChEMBL | Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis | B | 8.32 | pKi | 4.8 | nM | Ki | J Med Chem (2022) 65: 3371-3387 [PMID:35113565] |
| ChEMBL | Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2022) 65: 3371-3387 [PMID:35113565] |
| GtoPdb | - | - | 9.4 | pKi | 0.36 | nM | Ki | Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274] |
| ChEMBL | Inhibition of ACE (unknown origin) using Hippuryl-L-Histidyl-L-Leucine as substrate after 60 mins by colorimetric method | B | 8.1 | pIC50 | 7.92 | nM | IC50 | Eur J Med Chem (2017) 141: 417-426 [PMID:29032034] |
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Inhibitory activity against angiotensin converting enzyme (ACE) | F | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1993) 36: 2390-2403 [PMID:8360884] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1993) 36: 2051-2058 [PMID:8340909] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2002) 45: 5609-5616 [PMID:12477342] |
| ChEMBL | Inhibition of angiotensin-converting enzyme (unknown origin) | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2016) 59: 10865-10890 [PMID:27690430] |
| ChEMBL | Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serum | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (2003) 46: 3326-3332 [PMID:12852763] |
| ChEMBL | Inhibition of angiotensin converting enzyme (unknown origin) | B | 10 | pIC50 | 0.1 | nM | IC50 | Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823] |
| ChEMBL | Inhibition of human serum ACE | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 7216-7221 [PMID:24095015] |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibition of rabbit testis recombinant ACE C domain | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850] |
| ChEMBL | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method | B | 6.5 | pIC50 | 318 | nM | IC50 | Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179] |
| ChEMBL | Inhibition of rabbit lung ACE using hippuryl-histidyl-leucine as substrate assessed as release of hippuric acid incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometry | B | 6.55 | pIC50 | 281 | nM | IC50 | Bioorg Med Chem (2014) 22: 5824-5830 [PMID:25300819] |
| ChEMBL | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins | B | 6.58 | pIC50 | 262 | nM | IC50 | Bioorg Med Chem (2013) 21: 4485-4493 [PMID:23777825] |
| ChEMBL | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | B | 8.22 | pIC50 | 6.04 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
