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ChEMBL ligand: CHEMBL1237 (Lisinopril, MK-521, NSC-751176, NSC-758151, Prinivil, Zestril) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
ChEMBL | Inhibition of recombinant ACE N domain | B | 6.88 | pKi | 131.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850] |
ChEMBL | Inhibition of somatic ACE N domain | B | 6.88 | pKi | 131.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843] |
ChEMBL | Inhibition of testis ACE C domain | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4616-4619 [PMID:16784843] |
ChEMBL | Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis | B | 8.32 | pKi | 4.8 | nM | Ki | J Med Chem (2022) 65: 3371-3387 [PMID:35113565] |
ChEMBL | Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (2022) 65: 3371-3387 [PMID:35113565] |
GtoPdb | - | - | 9.4 | pKi | 0.36 | nM | Ki | Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274] |
ChEMBL | Inhibition of ACE (unknown origin) using Hippuryl-L-Histidyl-L-Leucine as substrate after 60 mins by colorimetric method | B | 8.1 | pIC50 | 7.92 | nM | IC50 | Eur J Med Chem (2017) 141: 417-426 [PMID:29032034] |
ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | Inhibitory activity against angiotensin converting enzyme (ACE) | F | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1993) 36: 2390-2403 [PMID:8360884] |
ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (2002) 45: 5609-5616 [PMID:12477342] |
ChEMBL | Inhibition of Angiotensin I converting enzyme | B | 8.92 | pIC50 | 1.2 | nM | IC50 | J Med Chem (1993) 36: 2051-2058 [PMID:8340909] |
ChEMBL | Inhibition of human serum ACE | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem (2013) 21: 7216-7221 [PMID:24095015] |
ChEMBL | Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serum | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (2003) 46: 3326-3332 [PMID:12852763] |
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
ChEMBL | Inhibition of rabbit testis recombinant ACE C domain | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 4612-4615 [PMID:16784850] |
ChEMBL | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method | B | 6.5 | pIC50 | 318 | nM | IC50 | Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179] |
ChEMBL | Inhibition of rabbit lung ACE using hippuryl-histidyl-leucine as substrate assessed as release of hippuric acid incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometry | B | 6.55 | pIC50 | 281 | nM | IC50 | Bioorg Med Chem (2014) 22: 5824-5830 [PMID:25300819] |
ChEMBL | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins | B | 6.58 | pIC50 | 262 | nM | IC50 | Bioorg Med Chem (2013) 21: 4485-4493 [PMID:23777825] |
ChEMBL | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | B | 8.22 | pIC50 | 6.04 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]