enalapril [Ligand Id: 6322] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL578 (C09AA02, Enalapril, Lexxel, Olinapril, Vaseretic, Vasotec) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| GtoPdb | - | - | 4.3 | pIC50 | 50000 | nM | IC50 | J Cardiovasc Pharmacol (1994) 23 Suppl 4: S11-5 [PMID:7527095] |
| ChEMBL | Compound tested in vitro for inhibition of Angiotensin I converting enzyme | B | 5.9 | pIC50 | 1273 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2002) 45: 5609-5616 [PMID:12477342] |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in Hog plasma | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | Compound was tested for its inhibitory potency against Angiotensin I converting enzyme | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1991) 34: 511-517 [PMID:1995872] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1985) 28: 1291-1295 [PMID:2993618] |
| ChEMBL | Inhibition of guinea pig angiotensin I converting enzyme | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1986) 29: 1953-1961 [PMID:3020249] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (1985) 28: 1603-1606 [PMID:2999394] |
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | In vitro inhibition against angiotensin converting enzyme (ACE) | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2673-2676 |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (1986) 29: 784-796 [PMID:3009814] |
| ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
| ChEMBL | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | B | 5.48 | pIC50 | 3330 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in rabbit lung | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method | B | 6.91 | pIC50 | 123 | nM | IC50 | Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179] |
| ChEMBL | Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro) | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1994) 37: 1823-1832 [PMID:8021921] |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1987) 30: 992-998 [PMID:3035180] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
