ChEMBL ligand: CHEMBL23293 (FTS, Salirasib)
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
Isoprenylcysteine carboxyl methyltransferase in Human [ChEMBL: CHEMBL4699] [UniProtKB: O60725] Isoprenylcysteine carboxyl methyltransferase in Rat [ChEMBL: CHEMBL2298] [UniProtKB: Q9WVM4] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analysis	B	5.51	pIC50	3100	nM	IC50	J Med Chem (2023) 66: 1928-1940 [PMID:36701569]
ChEMBL	Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) incubated for 2 hrs in presence of staurosporine by fluorescence based analysis	B	5.51	pIC50	3100	nM	IC50	J Med Chem (2023) 66: 1928-1940 [PMID:36701569]
Isoprenylcysteine carboxyl methyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4699] [UniProtKB: O60725]
ChEMBL	Inhibition of ICMT in cell free system	B	4.59	pIC50	25500	nM	IC50	ACS Med Chem Lett (2012) 3: 15-19 [PMID:22754607]
Isoprenylcysteine carboxyl methyltransferase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2298] [UniProtKB: Q9WVM4]
ChEMBL	Ability to inhibit prenylated protein methyltransferase (PPMTase) in cell free systems	B	5.55	pKi	2800	nM	Ki	J Med Chem (1995) 38: 1267-1272 [PMID:7731012]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against synchronized ring stage Plasmodium falciparum 3D7 transfected with nano-luciferase assessed as parasite growth inhibition after 72 hrs by Nano-Glo luciferase assay	F	4.69	pIC50	20340	nM	IC50	Medchemcomm (2019) 10: 1599-1605 [PMID:31803400]
ChEMBL	Antimalarial activity against synchronized ring stage Plasmodium falciparum 3D7 assessed as parasite growth inhibition measured after 24 to 96 hrs	F	4.85	pIC50	14000	nM	IC50	Medchemcomm (2019) 10: 1599-1605 [PMID:31803400]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-3/acetoxymethyl ester dye based FLIPR analysis	B	5.15	pEC50	7000	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
GtoPdb	FLIPR calcium-influx assay	-	5.3	pEC50	-	-	-	Mol Pharmacol (2008) 73: 1225-34 [PMID:18171730]
ChEMBL	Agonist activity at human TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels	F	5.3	pEC50	5000	nM	EC50	J Med Chem (2010) 53: 5085-5107 [PMID:20356305]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	6.08	pEC50	831.76	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]
ChEMBL	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	B	6.1	pEC50	800	nM	EC50	Eur J Med Chem (2019) 170: 141-156 [PMID:30878828]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]