PD 176252 [Ligand Id: 626] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL405908 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BB2 receptor/Gastrin releasing peptide receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4959] [GtoPdb: 39] [UniProtKB: P30550] | ||||||||
| GtoPdb | - | - | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 2589-94 [PMID:9873586] |
| ChEMBL | Antagonistic activity against cloned human Bombesin receptor bb2 labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells; 0.66-1.3 | F | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586] |
| GtoPdb | - | - | 6.77 | pIC50 | 170 | nM | IC50 | Peptides (2009) 30: 1473-86 [PMID:19463875] |
| GtoPdb | - | - | 6.77 | pIC50 | 170 | nM | IC50 | Peptides (2009) 30: 1473-86 [PMID:19463875] |
| ChEMBL | Antagonistic activity against labelled Bombesin receptor bb2 binding sites in rat cerebral cortex by using [125I]- [Tyr] bombesin in presence of NMB; 6.5-31 | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586] |
| BB1 receptor/Neuromedin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3636] [GtoPdb: 38] [UniProtKB: P28336] | ||||||||
| ChEMBL | Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells | F | 9.77 | pKi | 0.17 | nM | Ki | Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586] |
| ChEMBL | Antagonistic activity against labelled Bombesin receptor bb1 binding sites in rat olfactory bulb by using [125I]- [Tyr] bombesin in presence of [D-Phe-6] bombesin(6-13)ethyl ester; 0.31-1.3 | B | 9.18 | pIC50 | 0.66 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586] |
| GtoPdb | - | - | 9.77 | pIC50 | 0.17 | nM | IC50 | Peptides (2009) 30: 1473-86 [PMID:19463875] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
