PD 168368 [Ligand Id: 621] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL329650
Created with Highcharts 10.3.3ValuesChart context menuApelin receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • FPR1/Formyl peptide receptor 1 in Human [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
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  • BB2 receptor/Gastrin releasing peptide receptor in Human [ChEMBL: CHEMBL4959] [GtoPdb: 39] [UniProtKB: P30550]
Created with Highcharts 10.3.3ValuesChart context menuGastrin releasing peptide receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • BB1 receptor/Neuromedin B receptor in Human [ChEMBL: CHEMBL3636] [GtoPdb: 38] [UniProtKB: P28336]
  • BB1 receptor in Rat [GtoPdb: 38] [UniProtKB: P24053]
Created with Highcharts 10.3.3ValuesChart context menuNeuromedin B receptorpKd HumanpKi HumanpIC50 HumanpEC50 HumanpKd RatpKi RatpIC50 RatpEC50 Rat024681012Highcharts.com
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  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
Created with Highcharts 10.3.3ValuesChart context menuType-1 angiotensin II receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
apelin receptor/Apelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628481] [GtoPdb: 36] [UniProtKB: P35414]
ChEMBL GPCR PRESTO-Tango dose-response in antagonist mode with target: APLNR F 5 pIC50 >10000 nM IC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose
FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462]
ChEMBL GPCR PRESTO-Tango dose-response in antagonist mode with target: FPR1 F 5.41 pIC50 3865.03 nM IC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose
BB2 receptor/Gastrin releasing peptide receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4959] [GtoPdb: 39] [UniProtKB: P30550]
ChEMBL In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin. B 7.77 pKi 17 nM Ki Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586]
GtoPdb - - 7.82 pKi 15 nM Ki J Pharmacol Exp Ther (1999) 290: 1202-11 [PMID:10454496]
GtoPdb - - 5.93 pIC50 1172 nM IC50 Peptides (2009) 30: 1473-86 [PMID:19463875]
BB1 receptor/Neuromedin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3636] [GtoPdb: 38] [UniProtKB: P28336]
ChEMBL Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells F 9.82 pKi 0.15 nM Ki Bioorg Med Chem Lett (1998) 8: 2589-2594 [PMID:9873586]
GtoPdb - - 9.6 pIC50 0.25 nM IC50 Peptides (2009) 30: 1473-86 [PMID:19463875]
BB1 receptor in Rat [GtoPdb: 38] [UniProtKB: P24053]
GtoPdb - - 7.41 pIC50 39 nM IC50 J Pharmacol Exp Ther (1999) 290: 1202-11 [PMID:10454496]
GPR65/Psychosine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714081] [GtoPdb: 113] [UniProtKB: Q8IYL9]
ChEMBL GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR65 F 5.65 pIC50 2250.97 nM IC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL GPCR PRESTO-Tango dose-response in antagonist mode with target: AGTR1 F 5.43 pIC50 3697.15 nM IC50 EUbOPEN Chemogenomics Library - GPCR Dose-Respose

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]