ChEMBL ligand: CHEMBL1229535
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase catalytic subunit in Human [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol 4-kinase alpha/Phosphatidylinositol 4-kinase alpha in Human [ChEMBL: CHEMBL3667] [GtoPdb: 2148] [UniProtKB: P42356] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol 4-kinase beta/Phosphatidylinositol 4-kinase beta in Human [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in Human [ChEMBL: CHEMBL1075102] [GtoPdb: 2150] [UniProtKB: O00443] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta in Human [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
ChEMBL	Inhibition of human DNA-PK by non-radiometric ADP-Glo assay	B	7.19	pIC50	64	nM	IC50	ACS Med Chem Lett (2015) 6: 3-6 [PMID:25589915]
ChEMBL	Inhibition of DNA-PK (unknown origin)	B	7.19	pIC50	64	nM	IC50	J Med Chem (2017) 60: 47-65 [PMID:27644332]
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
ChEMBL	Inhibition of full length human recombinant VPS34 (unknown origin) using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or high-throughput membrane capture assay	B	6.49	pIC50	320	nM	IC50	J Med Chem (2017) 60: 47-65 [PMID:27644332]
ChEMBL	Inhibition of GST-tagged recombinant human full length VPS34 expressed in baculovirus preincubated for 15 mins followed by addition of cold ATP/gamma32P-ATP measured after 1 hr in presence of MnCl2	B	6.51	pIC50	307	nM	IC50	J Med Chem (2016) 59: 1830-1839 [PMID:26885694]
ChEMBL	Inhibition of human VPS34 assessed as reduction in PIP3 product complex formation	B	6.51	pEC50	307	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
ChEMBL	Inhibition of human VPS34 assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P ELISA assay	B	6.66	pEC50	220	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of PI3Kalpha (unknown origin)	B	7.41	pIC50	39	nM	IC50	Medchemcomm (2012) 3: 1337-1355
ChEMBL	Inhibition of PI3K alpha (unknown origin)	B	7.41	pIC50	39	nM	IC50	J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL	Inhibition of PI3K alpha (unknown origin) by membrane capture assay	B	7.41	pEC50	39	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL	Inhibition of PI3Kbeta (unknown origin)	B	6.23	pIC50	590	nM	IC50	Medchemcomm (2012) 3: 1337-1355
ChEMBL	Inhibition of PI3K beta (unknown origin) by membrane capture assay	B	6.23	pEC50	590	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
ChEMBL	Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation	B	6.23	pEC50	590	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
ChEMBL	Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P ELISA assay	B	6.27	pEC50	539	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL	Inhibition of PI3Kdelta (unknown origin)	B	6.92	pIC50	120	nM	IC50	Medchemcomm (2012) 3: 1337-1355
ChEMBL	Inhibition of histidine-tagged recombinant human full length PI3Kdelta expressed in baculovirus preincubated for 15 mins followed by addition of cold ATP/gamma32P-ATP measured after 20 mins in presence of MgCl2	B	7.11	pIC50	77	nM	IC50	J Med Chem (2016) 59: 1830-1839 [PMID:26885694]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL	Inhibition of PI3K-gamma (unknown origin)	B	8.15	pKi	7	nM	Ki	J Med Chem (2015) 58: 517-521 [PMID:24754609]
ChEMBL	Binding affinity to PI3Kgamma (unknown origin) assessed as inhibition constant	B	8.15	pKi	7	nM	Ki	J Med Chem (2024) 67: 10530-10547 [PMID:38988222]
ChEMBL	Inhibition of histidine-tagged recombinant human full length PI3Kgamma expressed in insect cells preincubated for 15 mins followed by addition of cold ATP/gamma32P-ATP measured after 15 mins in presence of MgCl2	B	7.77	pIC50	17	nM	IC50	J Med Chem (2016) 59: 1830-1839 [PMID:26885694]
ChEMBL	Inhibition of PI3Kgamma (unknown origin)	B	7.8	pIC50	16	nM	IC50	Medchemcomm (2012) 3: 1337-1355
ChEMBL	Inhibition of human PI3KCgamma by non-radiometric ADP-Glo assay	B	7.8	pIC50	16	nM	IC50	ACS Med Chem Lett (2015) 6: 3-6 [PMID:25589915]
ChEMBL	Inhibition of PI3Kgamma (unknown origin) using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or high-throughput membrane capture assay	B	7.8	pIC50	16	nM	IC50	J Med Chem (2017) 60: 47-65 [PMID:27644332]
ChEMBL	Inhibition of PI3K gamma (unknown origin) by membrane capture assay	B	8.4	pEC50	4	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol 4-kinase alpha/Phosphatidylinositol 4-kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3667] [GtoPdb: 2148] [UniProtKB: P42356]
ChEMBL	Inhibition of PI4K3alpha (unknown origin)	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2018) 61: 6705-6723 [PMID:29952567]
ChEMBL	Inhibition of PI4KA (unknown origin) by membrane capture assay	B	5.96	pEC50	1100	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol 4-kinase beta/Phosphatidylinositol 4-kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8]
ChEMBL	Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measuring reduction in [3H]thymidine incorporation preincubated for 5 days followed by [3H]thymidine addition measured after 18 hrs by liquid scintillation counting method	B	7.55	pIC50	28	nM	IC50	J Med Chem (2018) 61: 6705-6723 [PMID:29952567]
GtoPdb	-	-	7.72	pIC50	19	nM	IC50	Cell (2006) 125: 733-47 [PMID:16647110]; Mol Biol Cell (2008) 19: 711-21 [PMID:18077555]
ChEMBL	Inhibition of PI4K3beta (unknown origin)	B	7.72	pIC50	19	nM	IC50	J Med Chem (2018) 61: 6705-6723 [PMID:29952567]
ChEMBL	Inhibition of PI4KIIIbeta (unknown origin)	B	7.72	pIC50	19	nM	IC50	J Med Chem (2022) 65: 893-921 [PMID:33539089]
ChEMBL	Inhibition of PI4KB (unknown origin) by membrane capture assay	B	7.77	pEC50	17	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075102] [GtoPdb: 2150] [UniProtKB: O00443]
ChEMBL	Inhibition of human PI3KC2alpha by non-radiometric ADP-Glo assay	B	4.8	pIC50	16000	nM	IC50	ACS Med Chem Lett (2015) 6: 3-6 [PMID:25589915]
ChEMBL	Inhibition of PI3KC2alpha (unknown origin) expressed in HEK293 cells using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or high-throughput membrane capture assay	B	4.8	pIC50	16000	nM	IC50	J Med Chem (2017) 60: 47-65 [PMID:27644332]
ChEMBL	Inhibition of PIK3C2A (unknown origin) by membrane capture assay	B	4.8	pEC50	16000	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750]
ChEMBL	Inhibition of PI3KC2beta (unknown origin) expressed in HEK293 cells using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or high-throughput membrane capture assay	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2017) 60: 47-65 [PMID:27644332]
ChEMBL	Inhibition of human PI3KC2beta by non-radiometric ADP-Glo assay	B	6.85	pIC50	140	nM	IC50	ACS Med Chem Lett (2015) 6: 3-6 [PMID:25589915]
ChEMBL	Inhibition of PIK3C2B (unknown origin) by membrane capture assay	B	6.85	pEC50	140	nM	EC50	Biochemistry (2017) 56: 4326-4334 [PMID:28719179]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]