apelin-13 [Ligand Id: 605] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL414173
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
apelin receptor/Apelin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628481] [GtoPdb: 36] [UniProtKB: P35414]
GtoPdb - - 9.5 pIC50 - - - J Biol Chem (2000) 275: 21061-7 [PMID:10777510];
J Neurochem (2003) 84: 1162-1172 [PMID:12603839];
Biochemistry (2003) 42: 10163-8 [PMID:12939143]
ChEMBL Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization F 9.06 pEC50 0.87 nM EC50 Bioorg. Med. Chem. (2014) 22: 2992-2997 [PMID:24755525]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]