ChEMBL ligand: CHEMBL471901
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] There should be some charts here, you may need to enable JavaScript!
Lysyl-tRNA synthetase in Human [ChEMBL: CHEMBL5575] [UniProtKB: Q15046] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85]
ChEMBL	Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay	B	6.34	pIC50	456	nM	IC50	J Med Chem (2020) 63: 6784-6801 [PMID:32433887]
ChEMBL	Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubated for 15 mins followed by ATP addition and measured after 2 hrs by ADP-glo luminescence assay	B	6.36	pIC50	432	nM	IC50	J Med Chem (2020) 63: 6784-6801 [PMID:32433887]
Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046]
ChEMBL	Inhibition of human Syk	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem (2008) 16: 7347-7357 [PMID:18585046]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of SYK	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6231-6235 [PMID:18938080]
ChEMBL	Inhibition of recombinant Syk	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (2009) 19: 1944-1949 [PMID:19254842]
ChEMBL	Inhibition of spleen tyrosine kinase (unknown origin)	B	7.39	pIC50	41	nM	IC50	Eur J Med Chem (2013) 67: 434-446 [PMID:23917087]
GtoPdb	-	-	7.39	pIC50	41	nM	IC50	Bioorg Med Chem (2005) 13: 4936-51 [PMID:15990316]
ChEMBL	Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay	B	8.15	pIC50	7	nM	IC50	J Med Chem (2020) 63: 6784-6801 [PMID:32433887]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
GtoPdb	-	-	4.95	pIC50	11200	nM	IC50	Bioorg Med Chem (2005) 13: 4936-51 [PMID:15990316]
ChEMBL	Inhibition of human ZAP70	B	4.95	pIC50	11200	nM	IC50	Bioorg Med Chem (2008) 16: 7347-7357 [PMID:18585046]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]