ChEMBL ligand: CHEMBL313417 (SK-86002, SK&F-86002)
5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL	Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells	B	5	pIC50	10000	nM	IC50	J Med Chem (1996) 39: 3929-3937 [PMID:8831759]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle	B	5.27	pIC50	5400	nM	IC50	J Med Chem (1996) 39: 3929-3937 [PMID:8831759]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of p38alpha (unknown origin)	B	5.82	pIC50	1500	nM	IC50	J Med Chem (2022) 65: 15993-16032 [PMID:36490325]
ChEMBL	Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-pyrazol-1-yl)phenylamino)acetamide) from inactive form of p38alpha expressed in Escherichia coli BL21(DE3) cells by enzyme fragment complementation assay	B	6.09	pIC50	820	nM	IC50	J Med Chem (2010) 53: 357-367 [PMID:19928858]
ChEMBL	In vitro inhibitory concentration against Mitogen-activated protein kinase p38 alpha	B	6.4	pIC50	400	nM	IC50	J Med Chem (2003) 46: 4702-4713 [PMID:14561090]
ChEMBL	Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assay	B	6.96	pIC50	110	nM	IC50	J Med Chem (2010) 53: 357-367 [PMID:19928858]
GtoPdb	Measured using a classic homogeneous time-resolved fluorescence (HTRF) kinase assay	-	6.96	pIC50	110	nM	IC50	J Med Chem (2010) 53: 357-67 [PMID:19928858]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]