ChEMBL ligand: CHEMBL313417 (SK-86002, SK&F-86002)
5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL	Inhibitory concentration against 5-lipoxygenase in rat RBL-1 cells	B	5	pIC50	10000	nM	IC50	J Med Chem (1996) 39: 3929-3937 [PMID:8831759]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle	B	5.27	pIC50	5400	nM	IC50	J Med Chem (1996) 39: 3929-3937 [PMID:8831759]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-pyrazol-1-yl)phenylamino)acetamide) from inactive form of p38alpha expressed in Escherichia coli BL21(DE3) cells by enzyme fragment complementation assay	B	6.09	pIC50	820	nM	IC50	J Med Chem (2010) 53: 357-367 [PMID:19928858]
ChEMBL	In vitro inhibitory concentration against Mitogen-activated protein kinase p38 alpha	B	6.4	pIC50	400	nM	IC50	J Med Chem (2003) 46: 4702-4713 [PMID:14561090]
ChEMBL	Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assay	B	6.96	pIC50	110	nM	IC50	J Med Chem (2010) 53: 357-367 [PMID:19928858]
GtoPdb	Measured using a classic homogeneous time-resolved fluorescence (HTRF) kinase assay	-	6.96	pIC50	110	nM	IC50	J Med Chem (2010) 53: 357-67 [PMID:19928858]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]