Ro-32-0432 [Ligand Id: 6034] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL26501 (Ro-32-0432) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
| phosphorylase kinase catalytic subunit gamma 2/phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111324] [GtoPdb: 2147, 2145] [UniProtKB: P15735, P46019, P46020, Q16816, Q93100] | ||||||||
| ChEMBL | Inhibition of phosphorylase kinase (PhK) | B | 4.81 | pIC50 | 15625 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1303-1308 |
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Inhibition of PKCalpha | B | 7.66 | pIC50 | 22 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512] |
| protein kinase C alpha in Bovine [GtoPdb: 1482] | ||||||||
| GtoPdb | - | - | 8.05 | pIC50 | 9 | nM | IC50 |
J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006]; Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348] |
| protein kinase C alpha/Protein kinase C alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2855] [GtoPdb: 1482] [UniProtKB: P05696] | ||||||||
| ChEMBL | Inhibition of Protein kinase C alpha | B | 8.06 | pIC50 | 8.8 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1303-1308 |
| protein kinase C beta in Bovine [GtoPdb: 1483] | ||||||||
| GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 |
J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006]; Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348] |
| protein kinase C beta/Protein kinase C beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3020] [GtoPdb: 1483] [UniProtKB: P68403] | ||||||||
| ChEMBL | Inhibition of Protein kinase C beta | B | 7.52 | pIC50 | 30.5 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1303-1308 |
| ChEMBL | Inhibition of Protein kinase C beta 1 | B | 7.55 | pIC50 | 28 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1303-1308 |
| protein kinase C epsilon in Mouse [GtoPdb: 1486] [UniProtKB: P16054] | ||||||||
| GtoPdb | - | - | 6.97 | pIC50 | 108 | nM | IC50 |
J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006]; Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348] |
| protein kinase C epsilon/Protein kinase C epsilon in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3424] [GtoPdb: 1486] [UniProtKB: P09216] | ||||||||
| ChEMBL | Inhibition of Protein kinase C epsilon | B | 6.98 | pIC50 | 105 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1303-1308 |
| protein kinase C gamma in Bovine [GtoPdb: 1484] | ||||||||
| GtoPdb | - | - | 7.44 | pIC50 | 36.5 | nM | IC50 |
J Pharmacol Exp Ther (1994) 268: 922-9 [PMID:8114006]; Biochem J (1993) 294 ( Pt 2): 335-7 [PMID:8373348] |
| protein kinase C gamma/Protein kinase C gamma in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3604] [GtoPdb: 1484] [UniProtKB: P63319] | ||||||||
| ChEMBL | Inhibition of Protein kinase C gamma (PKC) | B | 7.44 | pIC50 | 36.5 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1303-1308 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
