ChEMBL ligand: CHEMBL288064
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL	Inhibition of CDK1/cyclinB	B	5	pIC50	10000	nM	IC50	Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Inhibition of human recombinant GSK3alpha	B	6.41	pIC50	390	nM	IC50	J Med Chem (2012) 55: 4407-4424 [PMID:22533818]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of human recombinant GSK3beta using pIRS-1 as substrate preincubated for 15 mins	B	6.1	pIC50	790	nM	IC50	J Med Chem (2012) 55: 4407-4424 [PMID:22533818]
ChEMBL	Inhibitory concentration against human Glycogen synthase kinase-3	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1525-1528 [PMID:12031334]
ChEMBL	Inhibition of GSK3-beta	B	6.41	pIC50	390	nM	IC50	Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
ChEMBL	Inhibition of GSK3beta (unknown origin)	B	6.41	pIC50	390	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539]
GtoPdb	-	-	6.41	pIC50	390	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1525-8 [PMID:12031334]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]